Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 30% ± 10% | |
mast cell | 19 studies | 26% ± 7% | |
B cell | 19 studies | 23% ± 8% | |
naive B cell | 19 studies | 37% ± 16% | |
macrophage | 12 studies | 24% ± 12% | |
myeloid cell | 9 studies | 23% ± 6% | |
capillary endothelial cell | 8 studies | 30% ± 2% | |
fibroblast | 8 studies | 22% ± 5% | |
vein endothelial cell | 7 studies | 36% ± 17% | |
microglial cell | 7 studies | 29% ± 10% | |
monocyte | 6 studies | 23% ± 3% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 6 studies | 20% ± 6% | |
endothelial cell of artery | 6 studies | 24% ± 7% | |
basal cell | 6 studies | 21% ± 5% | |
classical monocyte | 5 studies | 27% ± 8% | |
endothelial cell of vascular tree | 5 studies | 27% ± 12% | |
ciliated cell | 5 studies | 17% ± 3% | |
smooth muscle cell | 5 studies | 25% ± 4% | |
T cell | 4 studies | 17% ± 2% | |
gamma-delta T cell | 4 studies | 18% ± 2% | |
dendritic cell | 4 studies | 21% ± 5% | |
CD4-positive, alpha-beta memory T cell | 4 studies | 22% ± 7% | |
abnormal cell | 4 studies | 25% ± 8% | |
neutrophil | 3 studies | 19% ± 4% | |
glomerular endothelial cell | 3 studies | 39% ± 9% | |
pericyte | 3 studies | 23% ± 4% | |
myofibroblast cell | 3 studies | 24% ± 8% | |
epithelial cell | 3 studies | 25% ± 5% | |
germinal center B cell | 3 studies | 31% ± 9% | |
cholangiocyte | 3 studies | 44% ± 27% | |
hepatocyte | 3 studies | 47% ± 34% | |
type II pneumocyte | 3 studies | 20% ± 4% | |
brush cell | 3 studies | 24% ± 6% | |
goblet cell | 3 studies | 28% ± 4% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 12078.95 | 966 / 966 | 100% | 48.45 | 526 / 527 |
lung | 100% | 18641.86 | 578 / 578 | 99% | 51.11 | 1145 / 1155 |
esophagus | 100% | 11876.65 | 1445 / 1445 | 99% | 51.70 | 181 / 183 |
bladder | 100% | 10255.24 | 21 / 21 | 98% | 57.53 | 492 / 504 |
prostate | 100% | 8171.16 | 244 / 245 | 97% | 26.04 | 487 / 502 |
uterus | 100% | 6947.89 | 170 / 170 | 96% | 70.20 | 441 / 459 |
breast | 100% | 5725.08 | 457 / 459 | 96% | 33.47 | 1069 / 1118 |
thymus | 97% | 4052.35 | 633 / 653 | 98% | 31.64 | 592 / 605 |
liver | 100% | 9488.44 | 226 / 226 | 94% | 34.72 | 383 / 406 |
stomach | 95% | 7455.97 | 342 / 359 | 99% | 43.81 | 283 / 286 |
kidney | 97% | 5668.40 | 86 / 89 | 90% | 38.76 | 813 / 901 |
skin | 97% | 3538.51 | 1754 / 1809 | 84% | 21.22 | 398 / 472 |
pancreas | 65% | 2398.56 | 213 / 328 | 98% | 68.62 | 174 / 178 |
adrenal gland | 100% | 6580.13 | 257 / 258 | 50% | 9.05 | 115 / 230 |
ovary | 48% | 1698.64 | 86 / 180 | 65% | 12.93 | 278 / 430 |
lymph node | 0% | 0 | 0 / 0 | 100% | 195.20 | 29 / 29 |
spleen | 100% | 13844.55 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 27.55 | 1 / 1 |
adipose | 100% | 6903.58 | 1200 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 21204.93 | 923 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 5859.73 | 1325 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 79.44 | 44 / 45 |
brain | 30% | 871.08 | 781 / 2642 | 64% | 11.06 | 451 / 705 |
eye | 0% | 0 | 0 / 0 | 83% | 11.73 | 66 / 80 |
heart | 67% | 2574.03 | 577 / 861 | 0% | 0 | 0 / 0 |
muscle | 10% | 246.07 | 84 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0043306 | Biological process | positive regulation of mast cell degranulation |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_0032722 | Biological process | positive regulation of chemokine production |
GO_0045063 | Biological process | T-helper 1 cell differentiation |
GO_0002639 | Biological process | positive regulation of immunoglobulin production |
GO_0042832 | Biological process | defense response to protozoan |
GO_0007165 | Biological process | signal transduction |
GO_0045064 | Biological process | T-helper 2 cell differentiation |
GO_0035771 | Biological process | interleukin-4-mediated signaling pathway |
GO_0043032 | Biological process | positive regulation of macrophage activation |
GO_1901741 | Biological process | positive regulation of myoblast fusion |
GO_0006955 | Biological process | immune response |
GO_0002532 | Biological process | production of molecular mediator involved in inflammatory response |
GO_0016064 | Biological process | immunoglobulin mediated immune response |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0045626 | Biological process | negative regulation of T-helper 1 cell differentiation |
GO_0045630 | Biological process | positive regulation of T-helper 2 cell differentiation |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0043235 | Cellular component | receptor complex |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0034451 | Cellular component | centriolar satellite |
GO_0005654 | Cellular component | nucleoplasm |
GO_0004913 | Molecular function | interleukin-4 receptor activity |
GO_0004896 | Molecular function | cytokine receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | IL4R |
Protein name | Interleukin-4 receptor subunit alpha IL4R nirs variant 1 (Interleukin 4 receptor) Interleukin 4 receptor Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] |
Synonyms | 582J2.1 hCG_1984906 IL4RA |
Description | FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. .; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. . FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. . |
Accessions | J9JII2 ENST00000566117.5 H3BTD9 H3BSE7 ENST00000566318.5 A0A0G2JLA1 ENST00000568746.5 P24394 H3BRH7 I3L4W9 ENST00000395762.7 [P24394-1] ENST00000628578.1 ENST00000562968.1 ENST00000543915.6 [P24394-1] I3L4H7 Q5FC08 ENST00000562142.5 ENST00000561742.5 ENST00000563002.5 ENST00000565179.5 B9EGC0 ENST00000565352.1 ENST00000170630.6 [P24394-3] ENST00000563926.5 |