IL4R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043306Biological processpositive regulation of mast cell degranulation
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0032722Biological processpositive regulation of chemokine production
GO_0045063Biological processT-helper 1 cell differentiation
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0042832Biological processdefense response to protozoan
GO_0007165Biological processsignal transduction
GO_0045064Biological processT-helper 2 cell differentiation
GO_0035771Biological processinterleukin-4-mediated signaling pathway
GO_0043032Biological processpositive regulation of macrophage activation
GO_1901741Biological processpositive regulation of myoblast fusion
GO_0006955Biological processimmune response
GO_0002532Biological processproduction of molecular mediator involved in inflammatory response
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045626Biological processnegative regulation of T-helper 1 cell differentiation
GO_0045630Biological processpositive regulation of T-helper 2 cell differentiation
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0005654Cellular componentnucleoplasm
GO_0004913Molecular functioninterleukin-4 receptor activity
GO_0004896Molecular functioncytokine receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIL4R
Protein nameInterleukin-4 receptor subunit alpha
IL4R nirs variant 1 (Interleukin 4 receptor)
Interleukin 4 receptor
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
Synonyms582J2.1
hCG_1984906
IL4RA
DescriptionFUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. .; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. .

FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. .

AccessionsJ9JII2
ENST00000566117.5
H3BTD9
H3BSE7
ENST00000566318.5
A0A0G2JLA1
ENST00000568746.5
P24394
H3BRH7
I3L4W9
ENST00000395762.7 [P24394-1]
ENST00000628578.1
ENST00000562968.1
ENST00000543915.6 [P24394-1]
I3L4H7
Q5FC08
ENST00000562142.5
ENST00000561742.5
ENST00000563002.5
ENST00000565179.5
B9EGC0
ENST00000565352.1
ENST00000170630.6 [P24394-3]
ENST00000563926.5