Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 22 studies | 33% ± 11% | |
| monocyte | 11 studies | 24% ± 4% | |
| macrophage | 9 studies | 23% ± 6% | |
| neutrophil | 7 studies | 32% ± 10% | |
| non-classical monocyte | 4 studies | 16% ± 0% | |
| conventional dendritic cell | 4 studies | 26% ± 4% | |
| mononuclear phagocyte | 3 studies | 37% ± 14% |
Insufficient scRNA-seq data for expression of CLEC4E at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 1274.56 | 572 / 578 | 85% | 5.02 | 981 / 1155 |
| thymus | 90% | 626.45 | 586 / 653 | 63% | 2.46 | 382 / 605 |
| kidney | 56% | 143.17 | 50 / 89 | 84% | 6.51 | 759 / 901 |
| breast | 63% | 235.64 | 291 / 459 | 59% | 2.74 | 661 / 1118 |
| stomach | 44% | 96.63 | 159 / 359 | 69% | 3.99 | 198 / 286 |
| intestine | 55% | 106.24 | 530 / 966 | 56% | 2.88 | 293 / 527 |
| uterus | 47% | 86.26 | 80 / 170 | 59% | 2.45 | 269 / 459 |
| bladder | 48% | 123.24 | 10 / 21 | 53% | 2.40 | 266 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 46.55 | 29 / 29 |
| spleen | 100% | 2623.33 | 241 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 16% | 23.52 | 52 / 328 | 79% | 4.61 | 140 / 178 |
| brain | 20% | 40.44 | 521 / 2642 | 74% | 4.06 | 524 / 705 |
| prostate | 51% | 105.58 | 124 / 245 | 39% | 0.91 | 194 / 502 |
| ovary | 23% | 38.31 | 41 / 180 | 64% | 2.84 | 277 / 430 |
| esophagus | 30% | 52.22 | 433 / 1445 | 55% | 1.97 | 101 / 183 |
| adrenal gland | 48% | 72.73 | 124 / 258 | 35% | 0.93 | 81 / 230 |
| peripheral blood | 83% | 10680.34 | 772 / 929 | 0% | 0 | 0 / 0 |
| adipose | 82% | 425.09 | 986 / 1204 | 0% | 0 | 0 / 0 |
| skin | 12% | 17.57 | 222 / 1809 | 60% | 3.03 | 282 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 3.64 | 31 / 45 |
| blood vessel | 63% | 169.91 | 842 / 1335 | 0% | 0 | 0 / 0 |
| liver | 25% | 40.62 | 57 / 226 | 34% | 1.06 | 140 / 406 |
| heart | 32% | 53.35 | 272 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.18 | 6 / 80 |
| muscle | 3% | 4.11 | 28 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0061760 | Biological process | antifungal innate immune response |
| GO_0001819 | Biological process | positive regulation of cytokine production |
| GO_0002221 | Biological process | pattern recognition receptor signaling pathway |
| GO_0002292 | Biological process | T cell differentiation involved in immune response |
| GO_0038094 | Biological process | Fc-gamma receptor signaling pathway |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0045087 | Biological process | innate immune response |
| GO_0042995 | Cellular component | cell projection |
| GO_0001891 | Cellular component | phagocytic cup |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0030246 | Molecular function | carbohydrate binding |
| GO_0038187 | Molecular function | pattern recognition receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0051861 | Molecular function | glycolipid binding |
| Gene name | CLEC4E |
| Protein name | C-type lectin domain family 4 member E C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE) |
| Synonyms | UNQ218/PRO244 MINCLE CLECSF9 |
| Description | FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi . The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions . Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity). . |
| Accessions | ENST00000545274.5 F8WFA1 ENST00000446457.6 H0YGH9 Q9ULY5 ENST00000537698.1 ENST00000450725.2 F5H5X7 ENST00000299663.8 |
