MBL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MBL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MBL2 at tissue level.

III. Associated gene sets

GO_0050766Biological processpositive regulation of phagocytosis
GO_0006953Biological processacute-phase response
GO_0002752Biological processcell surface pattern recognition receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_1903028Biological processpositive regulation of opsonization
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0006958Biological processcomplement activation, classical pathway
GO_0048525Biological processnegative regulation of viral process
GO_0006508Biological processproteolysis
GO_0043129Biological processsurfactant homeostasis
GO_0042742Biological processdefense response to bacterium
GO_0008228Biological processopsonization
GO_0051873Biological processkilling by host of symbiont cells
GO_0006979Biological processresponse to oxidative stress
GO_0001867Biological processcomplement activation, lectin pathway
GO_0140374Biological processantiviral innate immune response
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005581Cellular componentcollagen trimer
GO_0009986Cellular componentcell surface
GO_0005771Cellular componentmultivesicular body
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0005537Molecular functionD-mannose binding
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMBL2
Protein nameMannose binding lectin
Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)
SynonymsMBL
COLEC1
DescriptionFUNCTION: Calcium-dependent lectin involved in innate immune defense . Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response . .

AccessionsENST00000675947.1
B1PN75
ENST00000674931.1
ENST00000373968.3
P11226