IL1R1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000661Biological processpositive regulation of interleukin-1-mediated signaling pathway
GO_2000556Biological processpositive regulation of T-helper 1 cell cytokine production
GO_0006954Biological processinflammatory response
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0070555Biological processresponse to interleukin-1
GO_0050727Biological processregulation of inflammatory response
GO_0006955Biological processimmune response
GO_2000391Biological processpositive regulation of neutrophil extravasation
GO_0032729Biological processpositive regulation of type II interferon production
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005161Molecular functionplatelet-derived growth factor receptor binding
GO_0004909Molecular functioninterleukin-1, type I, activating receptor activity
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0019966Molecular functioninterleukin-1 binding
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0002020Molecular functionprotease binding
GO_0004908Molecular functioninterleukin-1 receptor activity
GO_0005515Molecular functionprotein binding
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameIL1R1
Protein nameInterleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
Interleukin 1 receptor, type I
Interleukin 1 receptor type 1
SynonymsIL1R
IL1RA
IL1RT1
DescriptionFUNCTION: Receptor for IL1A, IL1B and IL1RN . After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells . .

AccessionsENST00000410023.6
ENST00000442590.5
H7BZM5
Q6NWP6
B9A040
C9J3W8
C9JQ36
P14778
ENST00000452403.5
ENST00000430171.1
ENST00000409288.5
ENST00000409929.5
Q6NWP5
F8WF92
ENST00000450319.5
B8ZZW4
ENST00000413623.5
ENST00000428279.5
C9JW84
ENST00000409589.5
B8ZZ73
ENST00000424272.5
C9JWB2
ENST00000422532.2
ENST00000409329.5
C9J686