Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 30 studies | 31% ± 15% | |
endothelial cell | 27 studies | 28% ± 11% | |
vein endothelial cell | 13 studies | 44% ± 15% | |
pericyte | 9 studies | 29% ± 12% | |
type II pneumocyte | 8 studies | 28% ± 6% | |
endothelial cell of vascular tree | 8 studies | 23% ± 4% | |
smooth muscle cell | 7 studies | 23% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 21% ± 5% | |
connective tissue cell | 5 studies | 24% ± 4% | |
epithelial cell | 5 studies | 36% ± 21% | |
adventitial cell | 5 studies | 29% ± 11% | |
mesothelial cell | 5 studies | 29% ± 11% | |
secretory cell | 5 studies | 24% ± 6% | |
club cell | 5 studies | 28% ± 9% | |
type I pneumocyte | 4 studies | 18% ± 3% | |
endothelial cell of sinusoid | 4 studies | 28% ± 9% | |
endothelial cell of artery | 4 studies | 17% ± 2% | |
hepatic stellate cell | 3 studies | 39% ± 16% | |
macrophage | 3 studies | 20% ± 3% | |
respiratory goblet cell | 3 studies | 29% ± 13% | |
hepatocyte | 3 studies | 51% ± 21% | |
basal cell | 3 studies | 31% ± 10% | |
myofibroblast cell | 3 studies | 47% ± 15% | |
group 3 innate lymphoid cell | 3 studies | 31% ± 10% | |
luminal cell of prostate epithelium | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 14177.31 | 244 / 245 | 100% | 122.11 | 502 / 502 |
lung | 100% | 24794.30 | 578 / 578 | 98% | 56.60 | 1131 / 1155 |
thymus | 100% | 12392.13 | 652 / 653 | 94% | 39.82 | 566 / 605 |
liver | 99% | 6262.41 | 224 / 226 | 94% | 33.86 | 380 / 406 |
breast | 100% | 16873.21 | 459 / 459 | 91% | 40.24 | 1019 / 1118 |
esophagus | 98% | 7463.58 | 1413 / 1445 | 93% | 37.62 | 170 / 183 |
kidney | 96% | 6362.28 | 85 / 89 | 86% | 31.03 | 777 / 901 |
bladder | 95% | 8748.19 | 20 / 21 | 80% | 28.06 | 401 / 504 |
stomach | 96% | 7328.22 | 345 / 359 | 77% | 25.81 | 220 / 286 |
pancreas | 76% | 3247.32 | 250 / 328 | 97% | 72.88 | 172 / 178 |
ovary | 77% | 6304.25 | 139 / 180 | 94% | 52.08 | 405 / 430 |
uterus | 94% | 6483.29 | 160 / 170 | 76% | 23.10 | 351 / 459 |
intestine | 96% | 8039.36 | 927 / 966 | 64% | 18.52 | 335 / 527 |
adrenal gland | 100% | 13988.09 | 258 / 258 | 58% | 21.83 | 134 / 230 |
skin | 100% | 15484.77 | 1805 / 1809 | 48% | 10.29 | 225 / 472 |
adipose | 100% | 24800.12 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 98% | 8528.11 | 235 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 97% | 8691.69 | 1298 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 84% | 25.52 | 38 / 45 |
heart | 79% | 5918.37 | 679 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 62% | 14.59 | 18 / 29 |
eye | 0% | 0 | 0 / 0 | 48% | 14.15 | 38 / 80 |
peripheral blood | 45% | 3566.08 | 416 / 929 | 0% | 0 | 0 / 0 |
muscle | 41% | 1509.49 | 327 / 803 | 0% | 0 | 0 / 0 |
brain | 7% | 257.82 | 197 / 2642 | 16% | 4.74 | 116 / 705 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2000661 | Biological process | positive regulation of interleukin-1-mediated signaling pathway |
GO_2000556 | Biological process | positive regulation of T-helper 1 cell cytokine production |
GO_0006954 | Biological process | inflammatory response |
GO_0070498 | Biological process | interleukin-1-mediated signaling pathway |
GO_0070555 | Biological process | response to interleukin-1 |
GO_0050727 | Biological process | regulation of inflammatory response |
GO_0006955 | Biological process | immune response |
GO_2000391 | Biological process | positive regulation of neutrophil extravasation |
GO_0032729 | Biological process | positive regulation of type II interferon production |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
GO_0004909 | Molecular function | interleukin-1, type I, activating receptor activity |
GO_0003953 | Molecular function | NAD+ nucleosidase activity |
GO_0019966 | Molecular function | interleukin-1 binding |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0002020 | Molecular function | protease binding |
GO_0004908 | Molecular function | interleukin-1 receptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0061809 | Molecular function | NAD+ nucleotidase, cyclic ADP-ribose generating |
Gene name | IL1R1 |
Protein name | Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)] Interleukin 1 receptor, type I Interleukin 1 receptor type 1 |
Synonyms | IL1R IL1RA IL1RT1 |
Description | FUNCTION: Receptor for IL1A, IL1B and IL1RN . After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells . . |
Accessions | ENST00000410023.6 ENST00000442590.5 H7BZM5 Q6NWP6 B9A040 C9J3W8 C9JQ36 P14778 ENST00000452403.5 ENST00000430171.1 ENST00000409288.5 ENST00000409929.5 Q6NWP5 F8WF92 ENST00000450319.5 B8ZZW4 ENST00000413623.5 ENST00000428279.5 C9JW84 ENST00000409589.5 B8ZZ73 ENST00000424272.5 C9JWB2 ENST00000422532.2 ENST00000409329.5 C9J686 |