CD3D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0045059Biological processpositive thymic T cell selection
GO_0046631Biological processalpha-beta T cell activation
GO_0050852Biological processT cell receptor signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0042105Cellular componentalpha-beta T cell receptor complex
GO_0042101Cellular componentT cell receptor complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD3D
Protein nameT-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
CD3 delta
T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain)
SynonymsT3D
hCG_40222
DescriptionFUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. .

AccessionsB0YIY4
ENST00000392884.2 [P04234-2]
E9PMT5
P04234
G8H453
ENST00000300692.9 [P04234-1]
ENST00000529594.5