SCNN1A | OmnibusX

Name	Number of supported studies	Average coverage
type I pneumocyte	11 studies	37% ± 9%	Explore
ciliated cell	11 studies	26% ± 10%	Explore
type II pneumocyte	9 studies	27% ± 10%	Explore
club cell	9 studies	30% ± 9%	Explore
basal cell	8 studies	29% ± 12%	Explore
epithelial cell	8 studies	40% ± 22%	Explore
respiratory goblet cell	8 studies	40% ± 9%	Explore
goblet cell	8 studies	48% ± 20%	Explore
ionocyte	6 studies	44% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 9%	Explore
mucus secreting cell	5 studies	25% ± 9%	Explore
duct epithelial cell	4 studies	38% ± 15%	Explore
secretory cell	4 studies	35% ± 13%	Explore
squamous epithelial cell	4 studies	52% ± 19%	Explore
renal alpha-intercalated cell	4 studies	31% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	38% ± 10%	Explore
renal principal cell	3 studies	39% ± 12%	Explore

Name	Number of supported studies	Average coverage
kidney	3 studies	24% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	11012.76	564 / 578	86%	133.20	994 / 1155
pancreas	96%	3742.71	316 / 328	85%	130.95	152 / 178
thymus	100%	16853.89	652 / 653	74%	98.52	447 / 605
prostate	89%	7661.91	219 / 245	67%	38.73	337 / 502
stomach	75%	7580.30	270 / 359	74%	71.15	213 / 286
kidney	100%	19086.09	89 / 89	44%	78.24	392 / 901
breast	59%	3768.34	271 / 459	79%	76.05	882 / 1118
intestine	44%	5543.07	427 / 966	91%	101.89	480 / 527
esophagus	39%	7285.32	563 / 1445	79%	89.52	145 / 183
bladder	48%	3105.24	10 / 21	64%	73.98	321 / 504
ovary	8%	159.11	15 / 180	98%	222.87	422 / 430
ureter	0%	0	0 / 0	100%	87.20	1 / 1
uterus	12%	843.44	21 / 170	68%	80.16	312 / 459
skin	73%	5883.56	1314 / 1809	3%	0.82	12 / 472
adrenal gland	63%	1622.05	162 / 258	1%	0.58	2 / 230
tonsil	0%	0	0 / 0	60%	70.15	27 / 45
liver	8%	146.01	19 / 226	7%	6.41	30 / 406
adipose	5%	113.76	66 / 1204	0%	0	0 / 0
muscle	0%	7.03	3 / 803	0%	0	0 / 0
heart	0%	6.75	3 / 861	0%	0	0 / 0
blood vessel	0%	3.61	2 / 1335	0%	0	0 / 0
peripheral blood	0%	6.25	1 / 929	0%	0	0 / 0
brain	0%	1.11	1 / 2642	0%	0	0 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

GO_0008217	Biological process	regulation of blood pressure
GO_0055078	Biological process	sodium ion homeostasis
GO_0050891	Biological process	multicellular organismal-level water homeostasis
GO_0006883	Biological process	intracellular sodium ion homeostasis
GO_0050914	Biological process	sensory perception of salty taste
GO_0071468	Biological process	cellular response to acidic pH
GO_0050915	Biological process	sensory perception of sour taste
GO_1904117	Biological process	cellular response to vasopressin
GO_1904045	Biological process	cellular response to aldosterone
GO_0098719	Biological process	sodium ion import across plasma membrane
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0016324	Cellular component	apical plasma membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0001669	Cellular component	acrosomal vesicle
GO_0005886	Cellular component	plasma membrane
GO_0031514	Cellular component	motile cilium
GO_0070062	Cellular component	extracellular exosome
GO_0034706	Cellular component	sodium channel complex
GO_0060170	Cellular component	ciliary membrane
GO_0097228	Cellular component	sperm principal piece
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0015280	Molecular function	ligand-gated sodium channel activity
GO_0050699	Molecular function	WW domain binding
GO_0005515	Molecular function	protein binding

Gene name	SCNN1A
Protein name	Amiloride-sensitive epithelial sodium channel alpha subunit Sodium channel epithelial 1 subunit alpha Amiloride-sensitive sodium channel subunit alpha 3 (Sodium channel epithelial 1 subunit alpha) Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Synonyms	SCNN1
Description	FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. .
Accessions	P37088 ENST00000338748.9 Q6UP09 C5HTY9 C5HTY8 ENST00000228916.7 [P37088-1] J3KPV6 ENST00000396966.6 C5HTZ1 ENST00000540037.5 ENST00000360168.7 [P37088-2] F5GXE6 F5H5F8 ENST00000536788.1 ENST00000543768.1 [P37088-6]

SCNN1A report