ALCAM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007155Biological processcell adhesion
GO_0048846Biological processaxon extension involved in axon guidance
GO_0002250Biological processadaptive immune response
GO_0008045Biological processmotor neuron axon guidance
GO_1990138Biological processneuron projection extension
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0001772Cellular componentimmunological synapse
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005925Cellular componentfocal adhesion
GO_0042101Cellular componentT cell receptor complex
GO_0030424Cellular componentaxon
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALCAM
Protein nameCD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
CD166 antigen (Activated leukocyte cell adhesion molecule)
SynonymsMEMD
DescriptionFUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts . Promotes T-cell activation and proliferation via its interactions with CD6 . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 . Mediates homotypic interactions with cells that express ALCAM . Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation . Required for normal hematopoietic stem cell engraftment in the bone marrow . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). .; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. .

AccessionsF5GXJ9
ENST00000306107.9 [Q13740-1]
ENST00000486979.6
ENST00000472644.6 [Q13740-2]
Q13740
ENST00000465413.6
H7C543