CALR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	54% ± 20%	Explore
endothelial cell	42 studies	52% ± 22%	Explore
natural killer cell	41 studies	53% ± 18%	Explore
B cell	40 studies	45% ± 13%	Explore
fibroblast	38 studies	56% ± 21%	Explore
CD8-positive, alpha-beta T cell	37 studies	51% ± 20%	Explore
T cell	33 studies	45% ± 16%	Explore
CD4-positive, alpha-beta T cell	30 studies	49% ± 19%	Explore
pericyte	29 studies	56% ± 20%	Explore
conventional dendritic cell	29 studies	58% ± 16%	Explore
plasma cell	26 studies	62% ± 25%	Explore
classical monocyte	26 studies	43% ± 19%	Explore
regulatory T cell	26 studies	52% ± 17%	Explore
smooth muscle cell	25 studies	48% ± 17%	Explore
dendritic cell	23 studies	53% ± 21%	Explore
non-classical monocyte	23 studies	49% ± 16%	Explore
endothelial cell of lymphatic vessel	22 studies	57% ± 20%	Explore
plasmacytoid dendritic cell	22 studies	63% ± 17%	Explore
epithelial cell	22 studies	56% ± 23%	Explore
mature NK T cell	20 studies	50% ± 16%	Explore
memory B cell	20 studies	45% ± 12%	Explore
naive B cell	20 studies	42% ± 12%	Explore
basal cell	20 studies	51% ± 18%	Explore
connective tissue cell	20 studies	59% ± 19%	Explore
monocyte	18 studies	45% ± 17%	Explore
gamma-delta T cell	18 studies	54% ± 14%	Explore
mast cell	17 studies	43% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	41% ± 9%	Explore
mucosal invariant T cell	16 studies	47% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	62% ± 13%	Explore
ciliated cell	16 studies	49% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	53% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	50% ± 11%	Explore
astrocyte	14 studies	30% ± 15%	Explore
myofibroblast cell	14 studies	58% ± 22%	Explore
capillary endothelial cell	13 studies	50% ± 17%	Explore
myeloid cell	13 studies	61% ± 21%	Explore
plasmablast	12 studies	79% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	56% ± 15%	Explore
secretory cell	12 studies	57% ± 14%	Explore
endothelial cell of artery	12 studies	55% ± 19%	Explore
vein endothelial cell	12 studies	54% ± 19%	Explore
endothelial cell of vascular tree	12 studies	46% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	55% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	53% ± 17%	Explore
abnormal cell	10 studies	55% ± 22%	Explore
mesothelial cell	10 studies	66% ± 22%	Explore
type I pneumocyte	9 studies	49% ± 20%	Explore
type II pneumocyte	9 studies	50% ± 21%	Explore
innate lymphoid cell	9 studies	46% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	64% ± 21%	Explore
leukocyte	9 studies	49% ± 17%	Explore
goblet cell	9 studies	50% ± 17%	Explore
IgG plasma cell	9 studies	48% ± 17%	Explore
club cell	8 studies	45% ± 18%	Explore
progenitor cell	8 studies	75% ± 11%	Explore
IgA plasma cell	8 studies	57% ± 16%	Explore
T follicular helper cell	8 studies	46% ± 9%	Explore
microglial cell	8 studies	37% ± 19%	Explore
alveolar macrophage	7 studies	51% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	40% ± 22%	Explore
neuron	7 studies	46% ± 20%	Explore
hematopoietic stem cell	7 studies	70% ± 11%	Explore
immature B cell	7 studies	53% ± 12%	Explore
hematopoietic precursor cell	6 studies	70% ± 22%	Explore
ionocyte	6 studies	49% ± 6%	Explore
respiratory goblet cell	6 studies	53% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	61% ± 17%	Explore
mononuclear phagocyte	6 studies	55% ± 21%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 24%	Explore
renal alpha-intercalated cell	6 studies	69% ± 9%	Explore
enterocyte	6 studies	47% ± 16%	Explore
precursor B cell	6 studies	62% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	58% ± 19%	Explore
oligodendrocyte precursor cell	6 studies	37% ± 13%	Explore
CD4-positive helper T cell	5 studies	38% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	47% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	53% ± 10%	Explore
exhausted T cell	5 studies	63% ± 15%	Explore
platelet	5 studies	27% ± 6%	Explore
GABAergic neuron	5 studies	27% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	69% ± 13%	Explore
transit amplifying cell	5 studies	51% ± 28%	Explore
erythroblast	5 studies	50% ± 31%	Explore
T-helper 17 cell	5 studies	56% ± 23%	Explore
mucus secreting cell	5 studies	36% ± 15%	Explore
hepatocyte	5 studies	45% ± 27%	Explore
granulocyte	5 studies	40% ± 12%	Explore
erythrocyte	5 studies	55% ± 19%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	62% ± 14%	Explore
deuterosomal cell	4 studies	31% ± 9%	Explore
squamous epithelial cell	4 studies	41% ± 23%	Explore
pancreatic A cell	4 studies	65% ± 11%	Explore
type B pancreatic cell	4 studies	56% ± 17%	Explore
glomerular endothelial cell	4 studies	51% ± 12%	Explore
enteroendocrine cell	4 studies	70% ± 12%	Explore
retinal ganglion cell	4 studies	35% ± 17%	Explore
retinal rod cell	4 studies	27% ± 8%	Explore
glial cell	4 studies	45% ± 26%	Explore
pro-B cell	4 studies	57% ± 12%	Explore
brush cell	4 studies	40% ± 9%	Explore
retinal pigment epithelial cell	4 studies	41% ± 24%	Explore
adventitial cell	4 studies	60% ± 12%	Explore
inflammatory macrophage	4 studies	43% ± 23%	Explore
muscle cell	4 studies	29% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	59% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	53% ± 14%	Explore
glutamatergic neuron	4 studies	34% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	65% ± 29%	Explore
group 3 innate lymphoid cell	4 studies	58% ± 11%	Explore
interneuron	4 studies	26% ± 7%	Explore
oligodendrocyte	4 studies	30% ± 9%	Explore
duct epithelial cell	3 studies	59% ± 2%	Explore
hillock cell	3 studies	45% ± 20%	Explore
precursor cell	3 studies	78% ± 10%	Explore
podocyte	3 studies	78% ± 11%	Explore
intestinal crypt stem cell	3 studies	50% ± 11%	Explore
neural crest cell	3 studies	61% ± 3%	Explore
retinal bipolar neuron	3 studies	25% ± 7%	Explore
renal principal cell	3 studies	71% ± 5%	Explore
extravillous trophoblast	3 studies	97% ± 1%	Explore
placental villous trophoblast	3 studies	94% ± 4%	Explore
common myeloid progenitor	3 studies	71% ± 11%	Explore
lymphocyte	3 studies	66% ± 9%	Explore
megakaryocyte	3 studies	35% ± 10%	Explore
neuroendocrine cell	3 studies	56% ± 19%	Explore
retinal cone cell	3 studies	45% ± 7%	Explore
serous secreting cell	3 studies	42% ± 5%	Explore
tissue-resident macrophage	3 studies	58% ± 27%	Explore
intraepithelial lymphocyte	3 studies	45% ± 20%	Explore
Mueller cell	3 studies	46% ± 5%	Explore
acinar cell	3 studies	31% ± 17%	Explore
neutrophil	3 studies	25% ± 11%	Explore
germinal center B cell	3 studies	45% ± 5%	Explore
intermediate monocyte	3 studies	74% ± 10%	Explore
myoepithelial cell	3 studies	71% ± 15%	Explore
endothelial cell of sinusoid	3 studies	44% ± 24%	Explore
IgM plasma cell	3 studies	63% ± 14%	Explore
pancreatic ductal cell	3 studies	69% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	87% ± 6%	Explore
keratinocyte	3 studies	39% ± 4%	Explore
T-helper 1 cell	3 studies	64% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	49% ± 14%	Explore
double negative thymocyte	3 studies	67% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	60% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	49% ± 18%	Explore
peripheral blood	19 studies	48% ± 13%	Explore
intestine	12 studies	48% ± 22%	Explore
brain	9 studies	32% ± 12%	Explore
kidney	9 studies	48% ± 19%	Explore
eye	8 studies	33% ± 18%	Explore
lymph node	7 studies	48% ± 19%	Explore
bone marrow	6 studies	45% ± 20%	Explore
liver	6 studies	46% ± 19%	Explore
prostate	5 studies	38% ± 15%	Explore
pancreas	4 studies	59% ± 15%	Explore
placenta	4 studies	70% ± 31%	Explore
uterus	4 studies	67% ± 10%	Explore
breast	4 studies	57% ± 7%	Explore
ovary	3 studies	32% ± 10%	Explore
heart	3 studies	27% ± 14%	Explore
adipose	3 studies	35% ± 13%	Explore
adrenal gland	3 studies	46% ± 20%	Explore
skin	3 studies	34% ± 10%	Explore
thymus	3 studies	58% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	19821.06	180 / 180	100%	1108.41	430 / 430
esophagus	100%	15375.46	1444 / 1445	100%	716.69	183 / 183
uterus	100%	17830.89	170 / 170	100%	1287.04	458 / 459
breast	100%	17409.51	459 / 459	100%	1051.07	1113 / 1118
thymus	100%	54055.16	653 / 653	100%	1485.13	602 / 605
lung	100%	24252.77	578 / 578	99%	1139.25	1148 / 1155
prostate	100%	15232.21	244 / 245	100%	1438.31	501 / 502
skin	100%	34570.90	1805 / 1809	100%	1174.69	470 / 472
intestine	100%	15469.52	964 / 966	99%	1032.88	523 / 527
stomach	100%	14747.46	359 / 359	99%	931.22	283 / 286
kidney	100%	19126.97	89 / 89	99%	887.50	891 / 901
pancreas	99%	13199.66	326 / 328	99%	845.47	177 / 178
liver	99%	29961.15	224 / 226	100%	1133.02	404 / 406
bladder	100%	15079.67	21 / 21	98%	1109.76	496 / 504
adrenal gland	100%	18647.17	257 / 258	96%	661.10	221 / 230
brain	95%	8455.28	2517 / 2642	100%	675.92	704 / 705
adipose	100%	18556.04	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	547.54	80 / 80
lymph node	0%	0	0 / 0	100%	1056.75	29 / 29
spleen	100%	19688.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	1105.11	45 / 45
ureter	0%	0	0 / 0	100%	517.72	1 / 1
blood vessel	100%	19589.57	1331 / 1335	0%	0	0 / 0
heart	97%	14727.85	833 / 861	0%	0	0 / 0
peripheral blood	93%	17271.36	867 / 929	0%	0	0 / 0
muscle	81%	4843.33	648 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033574	Biological process	response to testosterone
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0006611	Biological process	protein export from nucleus
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_2000510	Biological process	positive regulation of dendritic cell chemotaxis
GO_0050821	Biological process	protein stabilization
GO_0071257	Biological process	cellular response to electrical stimulus
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0071285	Biological process	cellular response to lithium ion
GO_0010628	Biological process	positive regulation of gene expression
GO_0042981	Biological process	regulation of apoptotic process
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0033144	Biological process	negative regulation of intracellular steroid hormone receptor signaling pathway
GO_0045787	Biological process	positive regulation of cell cycle
GO_0032355	Biological process	response to estradiol
GO_0051208	Biological process	sequestering of calcium ion
GO_0048387	Biological process	negative regulation of retinoic acid receptor signaling pathway
GO_1903416	Biological process	response to glycoside
GO_0002502	Biological process	peptide antigen assembly with MHC class I protein complex
GO_0040020	Biological process	regulation of meiotic nuclear division
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0036503	Biological process	ERAD pathway
GO_0017148	Biological process	negative regulation of translation
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0007283	Biological process	spermatogenesis
GO_0022417	Biological process	protein maturation by protein folding
GO_0055007	Biological process	cardiac muscle cell differentiation
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_1901164	Biological process	negative regulation of trophoblast cell migration
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0042921	Biological process	nuclear receptor-mediated glucocorticoid signaling pathway
GO_0006457	Biological process	protein folding
GO_0098586	Biological process	cellular response to virus
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0034504	Biological process	protein localization to nucleus
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_0090398	Biological process	cellular senescence
GO_0030866	Biological process	cortical actin cytoskeleton organization
GO_0044194	Cellular component	cytolytic granule
GO_0001669	Cellular component	acrosomal vesicle
GO_0005840	Cellular component	ribosome
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0033018	Cellular component	sarcoplasmic reticulum lumen
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0042824	Cellular component	MHC class I peptide loading complex
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0016020	Cellular component	membrane
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0071682	Cellular component	endocytic vesicle lumen
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005635	Cellular component	nuclear envelope
GO_0005925	Cellular component	focal adhesion
GO_0044322	Cellular component	endoplasmic reticulum quality control compartment
GO_0098553	Cellular component	lumenal side of endoplasmic reticulum membrane
GO_0005829	Cellular component	cytosol
GO_0060473	Cellular component	cortical granule
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0008270	Molecular function	zinc ion binding
GO_0005509	Molecular function	calcium ion binding
GO_0140313	Molecular function	molecular sequestering activity
GO_0044183	Molecular function	protein folding chaperone
GO_0051082	Molecular function	unfolded protein binding
GO_0005049	Molecular function	nuclear export signal receptor activity
GO_0042277	Molecular function	peptide binding
GO_0030246	Molecular function	carbohydrate binding
GO_0003729	Molecular function	mRNA binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0005506	Molecular function	iron ion binding
GO_0003723	Molecular function	RNA binding
GO_0050681	Molecular function	nuclear androgen receptor binding
GO_0005515	Molecular function	protein binding
GO_0003677	Molecular function	DNA binding
GO_0042562	Molecular function	hormone binding
GO_0005178	Molecular function	integrin binding
GO_0001849	Molecular function	complement component C1q complex binding

IV. Literature review

[source]

Gene name	CALR
Protein name	Calreticulin Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Synonyms	CRTC
Description	FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER . Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export . Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). .
Accessions	A0A142IKA2 ENST00000588454.6 K7ELE2 A0A142IK94 ENST00000586967.2 A0A7P0T861 ENST00000586967 A0A0F7W2W6 A0A0F7WAP3 P27797 ENST00000680816.1 K7EJB9 ENST00000316448.10 K7EL50 ENST00000586760.2 A0A142IKA1

CALR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review