CD163 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016192Biological processvesicle-mediated transport
GO_0006953Biological processacute-phase response
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0097110Molecular functionscaffold protein binding
GO_0005515Molecular functionprotein binding
GO_0005044Molecular functionscavenger receptor activity

IV. Literature review

[source]
Gene nameCD163
Protein nameScavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)]
CD163 molecule
SynonymsM130
DescriptionFUNCTION: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

AccessionsENST00000359156.8 [Q86VB7-1]
H0YFM0
ENST00000542280.5
ENST00000432237.3 [Q86VB7-3]
Q86VB7
ENST00000396620.7
ENST00000541972.5
ENST00000537626.5
H0YGZ7
F5GZZ9
C9JHR8