SLAMF7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLAMF7 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0030101Biological processnatural killer cell activation
GO_0007155Biological processcell adhesion
GO_0042110Biological processT cell activation
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameSLAMF7
Protein nameSLAM family member 7
SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
SynonymsUNQ576/PRO1138
CS1
DescriptionFUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway . Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K . In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion . In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines . .; FUNCTION: Isoform 3 does not mediate any NK cell activation.

AccessionsENST00000359331.8 [Q9NQ25-5]
ENST00000368042.7 [Q9NQ25-2]
ENST00000368043.8 [Q9NQ25-1]
ENST00000458602.6 [Q9NQ25-7]
ENST00000495334.1
ENST00000621377.4
B4DW98
Q9NQ25
ENST00000441662.6 [Q9NQ25-6]
ENST00000458104.6
R4GND0
B4DVL7
ENST00000444090.6 [Q9NQ25-4]