Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 21 studies | 19% ± 3% | |
plasma cell | 19 studies | 37% ± 12% | |
plasmacytoid dendritic cell | 13 studies | 30% ± 12% | |
CD16-positive, CD56-dim natural killer cell, human | 9 studies | 25% ± 9% | |
plasmablast | 8 studies | 38% ± 24% | |
conventional dendritic cell | 7 studies | 21% ± 5% | |
IgA plasma cell | 7 studies | 31% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 21% ± 2% | |
IgG plasma cell | 6 studies | 27% ± 9% | |
gamma-delta T cell | 5 studies | 21% ± 4% | |
non-classical monocyte | 4 studies | 25% ± 6% | |
CD8-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
dendritic cell | 4 studies | 23% ± 7% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 22% ± 2% | |
monocyte | 3 studies | 30% ± 4% | |
mature NK T cell | 3 studies | 21% ± 5% | |
macrophage | 3 studies | 19% ± 2% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 18% ± 2% | |
mucosal invariant T cell | 3 studies | 18% ± 1% |
Insufficient scRNA-seq data for expression of SLAMF7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 718.70 | 572 / 578 | 92% | 27.70 | 1058 / 1155 |
stomach | 67% | 353.56 | 242 / 359 | 71% | 15.05 | 202 / 286 |
breast | 58% | 222.98 | 265 / 459 | 71% | 13.97 | 797 / 1118 |
skin | 53% | 109.32 | 964 / 1809 | 74% | 31.52 | 347 / 472 |
intestine | 56% | 835.16 | 537 / 966 | 66% | 10.56 | 347 / 527 |
bladder | 57% | 308.00 | 12 / 21 | 63% | 11.04 | 318 / 504 |
esophagus | 40% | 159.03 | 577 / 1445 | 65% | 10.21 | 119 / 183 |
lymph node | 0% | 0 | 0 / 0 | 100% | 176.40 | 29 / 29 |
spleen | 100% | 4505.54 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 7548.40 | 920 / 929 | 0% | 0 | 0 / 0 |
liver | 74% | 144.60 | 167 / 226 | 24% | 3.77 | 96 / 406 |
tonsil | 0% | 0 | 0 / 0 | 93% | 30.46 | 42 / 45 |
uterus | 31% | 51.64 | 52 / 170 | 62% | 11.02 | 286 / 459 |
kidney | 30% | 116.17 | 27 / 89 | 60% | 9.68 | 543 / 901 |
prostate | 57% | 145.07 | 140 / 245 | 27% | 2.33 | 137 / 502 |
thymus | 44% | 229.68 | 285 / 653 | 40% | 7.32 | 241 / 605 |
pancreas | 8% | 12.58 | 25 / 328 | 70% | 9.49 | 125 / 178 |
adipose | 61% | 157.37 | 730 / 1204 | 0% | 0 | 0 / 0 |
ovary | 13% | 20.70 | 24 / 180 | 38% | 4.78 | 163 / 430 |
eye | 0% | 0 | 0 / 0 | 29% | 5.06 | 23 / 80 |
adrenal gland | 16% | 26.45 | 42 / 258 | 8% | 0.48 | 18 / 230 |
blood vessel | 23% | 77.17 | 308 / 1335 | 0% | 0 | 0 / 0 |
heart | 7% | 10.34 | 59 / 861 | 0% | 0 | 0 / 0 |
brain | 2% | 2.77 | 46 / 2642 | 3% | 0.38 | 21 / 705 |
muscle | 1% | 1.01 | 8 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0002250 | Biological process | adaptive immune response |
GO_0030101 | Biological process | natural killer cell activation |
GO_0007155 | Biological process | cell adhesion |
GO_0042110 | Biological process | T cell activation |
GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0042802 | Molecular function | identical protein binding |
Gene name | SLAMF7 |
Protein name | SLAM family member 7 SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) |
Synonyms | UNQ576/PRO1138 CS1 |
Description | FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway . Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K . In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion . In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines . .; FUNCTION: Isoform 3 does not mediate any NK cell activation. |
Accessions | ENST00000359331.8 [Q9NQ25-5] ENST00000368042.7 [Q9NQ25-2] ENST00000368043.8 [Q9NQ25-1] ENST00000458602.6 [Q9NQ25-7] ENST00000495334.1 ENST00000621377.4 B4DW98 Q9NQ25 ENST00000441662.6 [Q9NQ25-6] ENST00000458104.6 R4GND0 B4DVL7 ENST00000444090.6 [Q9NQ25-4] |