I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| neutrophil | 7 studies | 35% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| neutrophil | 7 studies | 35% ± 12% |
Insufficient scRNA-seq data for expression of CXCR2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 93% | 837.79 | 536 / 578 | 55% | 2.19 | 637 / 1155 |
| bladder | 48% | 311.10 | 10 / 21 | 52% | 2.29 | 262 / 504 |
| spleen | 99% | 3641.96 | 239 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 41% | 803.18 | 590 / 1445 | 57% | 4.07 | 104 / 183 |
| peripheral blood | 82% | 35082.05 | 758 / 929 | 0% | 0 | 0 / 0 |
| skin | 63% | 199.68 | 1134 / 1809 | 12% | 0.42 | 58 / 472 |
| stomach | 18% | 57.89 | 64 / 359 | 51% | 2.40 | 145 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 2.36 | 29 / 45 |
| intestine | 9% | 23.93 | 89 / 966 | 47% | 2.23 | 250 / 527 |
| uterus | 6% | 45.18 | 11 / 170 | 42% | 2.36 | 192 / 459 |
| kidney | 7% | 10.18 | 6 / 89 | 40% | 1.11 | 356 / 901 |
| brain | 5% | 9.12 | 125 / 2642 | 39% | 1.11 | 274 / 705 |
| pancreas | 2% | 5.09 | 7 / 328 | 40% | 1.30 | 71 / 178 |
| liver | 32% | 66.16 | 72 / 226 | 7% | 0.17 | 28 / 406 |
| prostate | 18% | 40.33 | 45 / 245 | 17% | 0.36 | 83 / 502 |
| adipose | 32% | 214.23 | 386 / 1204 | 0% | 0 | 0 / 0 |
| breast | 9% | 17.64 | 41 / 459 | 11% | 0.22 | 122 / 1118 |
| heart | 16% | 36.27 | 135 / 861 | 0% | 0 | 0 / 0 |
| ovary | 2% | 2.92 | 4 / 180 | 13% | 0.33 | 57 / 430 |
| thymus | 5% | 8.20 | 30 / 653 | 8% | 0.19 | 50 / 605 |
| adrenal gland | 1% | 1.00 | 2 / 258 | 8% | 0.17 | 19 / 230 |
| blood vessel | 9% | 34.92 | 119 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.20 | 2 / 29 |
| muscle | 1% | 2.09 | 11 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0038112 | Biological process | interleukin-8-mediated signaling pathway |
| GO_0031623 | Biological process | receptor internalization |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0007165 | Biological process | signal transduction |
| GO_0030593 | Biological process | neutrophil chemotaxis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0006968 | Biological process | cellular defense response |
| GO_0006955 | Biological process | immune response |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0042119 | Biological process | neutrophil activation |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0016020 | Cellular component | membrane |
| GO_0042629 | Cellular component | mast cell granule |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0009986 | Cellular component | cell surface |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0016494 | Molecular function | C-X-C chemokine receptor activity |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0019959 | Molecular function | interleukin-8 binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004918 | Molecular function | interleukin-8 receptor activity |
| Gene name | CXCR2 |
| Protein name | C-X-C motif chemokine receptor 2 (Interleukin-8 receptor type B) C-X-C chemokine receptor type 2 (High affinity interleukin-8 receptor B) C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) |
| Synonyms | IL8RB |
| Description | FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor . Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system . Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. . |
| Accessions | C9J2F9 ENST00000318507.7 ENST00000418878.1 P25025 C9J1J7 C9JG19 ENST00000428565.1 C9JW47 ENST00000454148.1 Q6LCZ7 ENST00000415392.5 ENST00000449014.5 ENST00000453237.5 |
