I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 7 studies | 30% ± 12% | |
| epithelial cell | 4 studies | 22% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 7 studies | 30% ± 12% | |
| epithelial cell | 4 studies | 22% ± 7% |
Insufficient scRNA-seq data for expression of AMOT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 3763.06 | 2602 / 2642 | 98% | 39.55 | 693 / 705 |
| kidney | 100% | 1497.31 | 89 / 89 | 92% | 20.04 | 828 / 901 |
| thymus | 96% | 1013.73 | 629 / 653 | 94% | 20.76 | 568 / 605 |
| ovary | 98% | 1000.90 | 176 / 180 | 92% | 20.99 | 395 / 430 |
| prostate | 98% | 1441.70 | 241 / 245 | 88% | 12.18 | 443 / 502 |
| intestine | 97% | 1050.22 | 937 / 966 | 85% | 14.75 | 450 / 527 |
| breast | 91% | 1304.37 | 419 / 459 | 90% | 17.88 | 1011 / 1118 |
| skin | 82% | 667.46 | 1475 / 1809 | 80% | 17.00 | 377 / 472 |
| uterus | 99% | 1430.94 | 169 / 170 | 59% | 11.37 | 271 / 459 |
| bladder | 95% | 999.24 | 20 / 21 | 54% | 9.18 | 273 / 504 |
| stomach | 55% | 408.12 | 197 / 359 | 83% | 14.25 | 236 / 286 |
| esophagus | 80% | 685.04 | 1150 / 1445 | 57% | 8.45 | 104 / 183 |
| lung | 66% | 441.23 | 380 / 578 | 63% | 10.02 | 731 / 1155 |
| muscle | 100% | 4827.67 | 800 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 24% | 130.67 | 78 / 328 | 75% | 7.78 | 133 / 178 |
| blood vessel | 98% | 1152.02 | 1308 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 30% | 160.75 | 77 / 258 | 54% | 5.66 | 125 / 230 |
| adipose | 84% | 877.22 | 1012 / 1204 | 0% | 0 | 0 / 0 |
| heart | 67% | 594.54 | 575 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 63% | 6.67 | 50 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 47% | 7.20 | 21 / 45 |
| liver | 18% | 95.41 | 40 / 226 | 20% | 1.55 | 80 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 4.03 | 6 / 29 |
| spleen | 18% | 85.58 | 43 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 6% | 92.17 | 56 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0090162 | Biological process | establishment of epithelial cell polarity |
| GO_0035329 | Biological process | hippo signaling |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0040019 | Biological process | positive regulation of embryonic development |
| GO_0043534 | Biological process | blood vessel endothelial cell migration |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0042074 | Biological process | cell migration involved in gastrulation |
| GO_0008104 | Biological process | protein localization |
| GO_0003365 | Biological process | establishment of cell polarity involved in ameboidal cell migration |
| GO_0001702 | Biological process | gastrulation with mouth forming second |
| GO_0001726 | Cellular component | ruffle |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005884 | Cellular component | actin filament |
| GO_0005829 | Cellular component | cytosol |
| GO_0008180 | Cellular component | COP9 signalosome |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0030054 | Cellular component | cell junction |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0043532 | Molecular function | angiostatin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AMOT |
| Protein name | Angiomotin AMOT protein |
| Synonyms | KIAA1071 |
| Description | FUNCTION: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. . |
| Accessions | ENST00000371959.9 [Q4VCS5-1] E7ERM3 ENST00000371962.5 Q4VCS5 ENST00000371958.1 ENST00000304758.5 [Q4VCS5-2] A2BDD9 A6NP16 |
