COLEC11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of COLEC11 at tissue level.

III. Associated gene sets

GO_0002752Biological processcell surface pattern recognition receptor signaling pathway
GO_0032502Biological processdevelopmental process
GO_1903028Biological processpositive regulation of opsonization
GO_0006956Biological processcomplement activation
GO_0019730Biological processantimicrobial humoral response
GO_0006508Biological processproteolysis
GO_0097194Biological processexecution phase of apoptosis
GO_0001867Biological processcomplement activation, lectin pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005581Cellular componentcollagen trimer
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0003677Molecular functionDNA binding
GO_0120153Molecular functioncalcium-dependent carbohydrate binding
GO_0005537Molecular functionD-mannose binding
GO_0042802Molecular functionidentical protein binding
GO_0042806Molecular functionfucose binding
GO_0070492Molecular functionoligosaccharide binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOLEC11
Protein nameCollectin-11 (Collectin kidney protein 1) (CL-K1)
Collectin subfamily member 11
SynonymsUNQ596/PRO1182
DescriptionFUNCTION: Lectin that plays a role in innate immunity, apoptosis and embryogenesis . Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope . Primarily recognizes the terminal disaccharide of the glycan . Also recognizes a subset of fucosylated glycans and lipopolysaccharides . Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 . Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis . .

AccessionsENST00000438814.5
C9JWT5
F8WB29
ENST00000382062.6 [Q9BWP8-3]
ENST00000416132.5
ENST00000402922.2 [Q9BWP8-7]
ENST00000404205.5 [Q9BWP8-8]
ENST00000403096.7 [Q9BWP8-4]
ENST00000349077.9 [Q9BWP8-1]
ENST00000236693.11 [Q9BWP8-9]
ENST00000402794.4 [Q9BWP8-6]
ENST00000418971.6 [Q9BWP8-10]
Q9BWP8