Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 6 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 4342.96 | 2557 / 2642 | 100% | 64.45 | 702 / 705 |
| thymus | 100% | 5380.58 | 651 / 653 | 97% | 26.65 | 584 / 605 |
| breast | 100% | 12832.34 | 459 / 459 | 90% | 16.58 | 1011 / 1118 |
| lung | 100% | 11036.42 | 578 / 578 | 83% | 12.91 | 963 / 1155 |
| adrenal gland | 87% | 1801.92 | 224 / 258 | 90% | 18.60 | 208 / 230 |
| prostate | 79% | 1840.89 | 193 / 245 | 81% | 10.16 | 406 / 502 |
| stomach | 81% | 1782.42 | 292 / 359 | 77% | 12.91 | 219 / 286 |
| intestine | 90% | 2731.09 | 870 / 966 | 67% | 8.48 | 354 / 527 |
| esophagus | 79% | 2533.59 | 1148 / 1445 | 75% | 11.91 | 137 / 183 |
| kidney | 75% | 1598.40 | 67 / 89 | 78% | 42.24 | 699 / 901 |
| bladder | 90% | 3140.71 | 19 / 21 | 60% | 6.88 | 303 / 504 |
| uterus | 96% | 3420.99 | 163 / 170 | 41% | 6.07 | 190 / 459 |
| skin | 80% | 2159.69 | 1444 / 1809 | 54% | 6.93 | 255 / 472 |
| pancreas | 25% | 348.80 | 83 / 328 | 94% | 19.66 | 167 / 178 |
| liver | 27% | 382.60 | 62 / 226 | 80% | 11.29 | 324 / 406 |
| adipose | 100% | 14964.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5524.30 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 4866.93 | 855 / 861 | 0% | 0 | 0 / 0 |
| muscle | 88% | 2120.47 | 710 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 88% | 3221.68 | 1169 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 38% | 788.67 | 68 / 180 | 43% | 3.71 | 184 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 14.41 | 22 / 29 |
| peripheral blood | 64% | 1936.64 | 596 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 5.93 | 27 / 45 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.72 | 6 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0061384 | Biological process | heart trabecula morphogenesis |
| GO_0001955 | Biological process | blood vessel maturation |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0045446 | Biological process | endothelial cell differentiation |
| GO_0030032 | Biological process | lamellipodium assembly |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0045124 | Biological process | regulation of bone resorption |
| GO_0003245 | Biological process | cardiac muscle tissue growth involved in heart morphogenesis |
| GO_0030500 | Biological process | regulation of bone mineralization |
| GO_0006935 | Biological process | chemotaxis |
| GO_0007155 | Biological process | cell adhesion |
| GO_0030595 | Biological process | leukocyte chemotaxis |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0003376 | Biological process | sphingosine-1-phosphate receptor signaling pathway |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0007420 | Biological process | brain development |
| GO_0019226 | Biological process | transmission of nerve impulse |
| GO_0050927 | Biological process | positive regulation of positive chemotaxis |
| GO_0030155 | Biological process | regulation of cell adhesion |
| GO_0072678 | Biological process | T cell migration |
| GO_0016477 | Biological process | cell migration |
| GO_0019222 | Biological process | regulation of metabolic process |
| GO_0051497 | Biological process | negative regulation of stress fiber assembly |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005768 | Cellular component | endosome |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0046625 | Molecular function | sphingolipid binding |
| GO_0001664 | Molecular function | G protein-coupled receptor binding |
| GO_0038036 | Molecular function | sphingosine-1-phosphate receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | S1PR1 |
| Protein name | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) Sphingosine-1-phosphate receptor 1 |
| Synonyms | EDG1 CHEDG1 |
| Description | FUNCTION: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. . |
| Accessions | ENST00000649383.1 ENST00000648480.1 ENST00000305352.7 ENST00000475821.2 P21453 ENST00000475289.2 A0A3B3IUD4 |
