FOLR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	14 studies	42% ± 19%	Explore
type I pneumocyte	10 studies	66% ± 25%	Explore
type II pneumocyte	9 studies	54% ± 20%	Explore
club cell	7 studies	36% ± 25%	Explore
epithelial cell of proximal tubule	6 studies	28% ± 6%	Explore
epithelial cell	5 studies	38% ± 20%	Explore
basal cell	5 studies	30% ± 13%	Explore
secretory cell	5 studies	47% ± 24%	Explore
duct epithelial cell	4 studies	62% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 7%	Explore
mucus secreting cell	4 studies	56% ± 26%	Explore
abnormal cell	3 studies	33% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	3 studies	28% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	3281.81	89 / 89	81%	121.93	734 / 901
thymus	100%	1410.08	653 / 653	73%	53.86	441 / 605
lung	100%	4245.02	577 / 578	56%	157.06	652 / 1155
pancreas	68%	113.11	223 / 328	38%	28.87	67 / 178
ovary	6%	17.71	10 / 180	98%	724.84	422 / 430
stomach	74%	467.43	267 / 359	16%	12.83	46 / 286
breast	53%	397.45	243 / 459	17%	18.45	194 / 1118
adrenal gland	36%	60.57	94 / 258	3%	1.35	6 / 230
uterus	11%	117.88	18 / 170	23%	35.70	105 / 459
skin	31%	45.66	567 / 1809	1%	0.77	6 / 472
prostate	31%	47.83	76 / 245	0%	0	0 / 502
esophagus	10%	49.20	142 / 1445	12%	7.23	22 / 183
brain	17%	54.05	446 / 2642	5%	3.28	35 / 705
intestine	1%	2.34	7 / 966	15%	15.17	81 / 527
bladder	0%	0	0 / 21	10%	23.95	52 / 504
liver	0%	0	0 / 226	5%	4.25	20 / 406
heart	1%	1.50	11 / 861	0%	0	0 / 0
adipose	1%	0.94	10 / 1204	0%	0	0 / 0
peripheral blood	1%	1.50	5 / 929	0%	0	0 / 0
muscle	0%	0.87	4 / 803	0%	0	0 / 0
blood vessel	0%	0.96	4 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0031103	Biological process	axon regeneration
GO_0061713	Biological process	anterior neural tube closure
GO_0035036	Biological process	sperm-egg recognition
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0071231	Biological process	cellular response to folic acid
GO_0001947	Biological process	heart looping
GO_0007155	Biological process	cell adhesion
GO_0046655	Biological process	folic acid metabolic process
GO_0003147	Biological process	neural crest cell migration involved in heart formation
GO_0003253	Biological process	cardiac neural crest cell migration involved in outflow tract morphogenesis
GO_0007342	Biological process	fusion of sperm to egg plasma membrane involved in single fertilization
GO_0060828	Biological process	regulation of canonical Wnt signaling pathway
GO_0061626	Biological process	pharyngeal arch artery morphogenesis
GO_0015884	Biological process	folic acid transport
GO_0031526	Cellular component	brush border membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0030136	Cellular component	clathrin-coated vesicle
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0030133	Cellular component	transport vesicle
GO_0012507	Cellular component	ER to Golgi transport vesicle membrane
GO_0005768	Cellular component	endosome
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0038023	Molecular function	signaling receptor activity
GO_0005542	Molecular function	folic acid binding
GO_0005515	Molecular function	protein binding
GO_0061714	Molecular function	folic acid receptor activity

IV. Literature review

[source]

Gene name	FOLR1
Protein name	Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18) Folate receptor alpha
Synonyms	FOLR
Description	FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells . Has high affinity for folate and folic acid analogs at neutral pH . Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release . Required for normal embryonic development and normal cell proliferation (By similarity). .
Accessions	A0A650DFB4 ENST00000312293.9 ENST00000393681.6 A0A650DF41 A0A650DF39 A0A650DF42 P15328 ENST00000393679.5 ENST00000393676.5 ENST00000675784.1 A0A650DF38

FOLR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review