NEU3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900186Biological processnegative regulation of clathrin-dependent endocytosis
GO_0005975Biological processcarbohydrate metabolic process
GO_0046479Biological processglycosphingolipid catabolic process
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0009313Biological processoligosaccharide catabolic process
GO_0006689Biological processganglioside catabolic process
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005737Cellular componentcytoplasm
GO_0005901Cellular componentcaveola
GO_0005765Cellular componentlysosomal membrane
GO_0016997Molecular functionalpha-sialidase activity
GO_0052795Molecular functionexo-alpha-(2->6)-sialidase activity
GO_0052796Molecular functionexo-alpha-(2->8)-sialidase activity
GO_0052794Molecular functionexo-alpha-(2->3)-sialidase activity
GO_0005515Molecular functionprotein binding
GO_0004308Molecular functionexo-alpha-sialidase activity

IV. Literature review

[source]
Gene nameNEU3
Protein nameSialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3)
Neuraminidase 3
Synonyms
DescriptionFUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 . Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR . Desialylates EGFR and activates downstream signaling in proliferating cells . Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes . .

AccessionsQ9UQ49
ENST00000531509.5 [Q9UQ49-2]
ENST00000531619.1
ENST00000534628.1
ENST00000529024.1
E9PR25
ENST00000532963.1
E9PNK1
ENST00000526068.1
E9PI40
ENST00000294064.9 [Q9UQ49-2]
E9PMZ3