Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 33 studies | 40% ± 18% | |
| memory B cell | 18 studies | 44% ± 12% | |
| naive B cell | 17 studies | 45% ± 12% | |
| precursor B cell | 7 studies | 53% ± 12% | |
| plasma cell | 6 studies | 29% ± 11% | |
| immature B cell | 6 studies | 55% ± 10% | |
| pro-B cell | 4 studies | 30% ± 7% | |
| plasmablast | 3 studies | 38% ± 8% | |
| germinal center B cell | 3 studies | 54% ± 14% |
Insufficient scRNA-seq data for expression of CD19 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 76% | 85.69 | 440 / 578 | 77% | 5.20 | 889 / 1155 |
| ovary | 71% | 45.53 | 127 / 180 | 49% | 1.41 | 212 / 430 |
| intestine | 60% | 1080.40 | 580 / 966 | 51% | 5.06 | 271 / 527 |
| stomach | 49% | 69.17 | 176 / 359 | 59% | 7.32 | 169 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 328.89 | 29 / 29 |
| spleen | 100% | 9020.71 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 2002.77 | 917 / 929 | 0% | 0 | 0 / 0 |
| bladder | 43% | 66.81 | 9 / 21 | 44% | 3.89 | 224 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 10.97 | 35 / 45 |
| esophagus | 26% | 46.75 | 381 / 1445 | 47% | 2.20 | 86 / 183 |
| kidney | 51% | 98.44 | 45 / 89 | 15% | 0.84 | 139 / 901 |
| prostate | 43% | 73.23 | 106 / 245 | 21% | 0.96 | 106 / 502 |
| uterus | 20% | 9.61 | 34 / 170 | 44% | 1.91 | 203 / 459 |
| thymus | 23% | 193.34 | 153 / 653 | 32% | 4.92 | 194 / 605 |
| breast | 16% | 13.29 | 74 / 459 | 37% | 2.78 | 412 / 1118 |
| pancreas | 2% | 0.81 | 7 / 328 | 48% | 7.51 | 86 / 178 |
| liver | 32% | 17.66 | 73 / 226 | 17% | 1.89 | 70 / 406 |
| skin | 0% | 0.50 | 9 / 1809 | 47% | 6.92 | 224 / 472 |
| adrenal gland | 11% | 4.99 | 29 / 258 | 14% | 0.52 | 32 / 230 |
| adipose | 17% | 30.18 | 210 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 9% | 36.06 | 123 / 1335 | 0% | 0 | 0 / 0 |
| brain | 2% | 0.75 | 41 / 2642 | 5% | 1.24 | 36 / 705 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.41 | 5 / 80 |
| heart | 5% | 5.92 | 47 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.24 | 4 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051281 | Biological process | positive regulation of release of sequestered calcium ion into cytosol |
| GO_0050851 | Biological process | antigen receptor-mediated signaling pathway |
| GO_0050853 | Biological process | B cell receptor signaling pathway |
| GO_0001923 | Biological process | B-1 B cell differentiation |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0050855 | Biological process | regulation of B cell receptor signaling pathway |
| GO_0016064 | Biological process | immunoglobulin mediated immune response |
| GO_0002322 | Biological process | B cell proliferation involved in immune response |
| GO_0050864 | Biological process | regulation of B cell activation |
| GO_0045121 | Cellular component | membrane raft |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| Gene name | CD19 |
| Protein name | CD19 antigen, isoform CRA_a (cDNA FLJ54955, highly similar to B-lymphocyte antigen CD19) Alternative protein CD19 B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19) CD19 CD19 antigen, isoform CRA_f (cDNA FLJ60916, highly similar to B-lymphocyte antigen CD19) |
| Synonyms | hCG_18515 |
| Description | FUNCTION: Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge . . |
| Accessions | ENST00000324662.8 [P15391-2] Q71UW0 ENST00000538922.8 [P15391-1] P15391 B4DW45 B4E2W1 L8E9X3 |
