CD3G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070228Biological processregulation of lymphocyte apoptotic process
GO_0046629Biological processgamma-delta T cell activation
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0046631Biological processalpha-beta T cell activation
GO_0050852Biological processT cell receptor signaling pathway
GO_0065003Biological processprotein-containing complex assembly
GO_0002250Biological processadaptive immune response
GO_0015031Biological processprotein transport
GO_0045059Biological processpositive thymic T cell selection
GO_0042110Biological processT cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0042105Cellular componentalpha-beta T cell receptor complex
GO_0005829Cellular componentcytosol
GO_0042106Cellular componentgamma-delta T cell receptor complex
GO_0042608Molecular functionT cell receptor binding
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD3G
Protein nameTCR Ti gamma-chain V9-J2 region
T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain)
T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
TCR Ti gamma-chain V8-J2 region
CD3 gamma subunit of T-cell receptor complex
SynonymsT3G
hCG_1646880
DescriptionFUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface . Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. .

AccessionsENST00000392883.6
A8MUH3
A2N8H5
P09693
ENST00000528540.5
A0A3B3IUD8
ENST00000292144.8
B0YIY5
ENST00000532917.3
A2N8H4
J3KNA5