CD28 | OmnibusX

Name	Number of supported studies	Average coverage
regulatory T cell	22 studies	31% ± 7%	Explore
CD4-positive, alpha-beta T cell	20 studies	24% ± 7%	Explore
T cell	11 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	19% ± 4%	Explore
macrophage	9 studies	21% ± 5%	Explore
mucosal invariant T cell	8 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 8%	Explore
T follicular helper cell	6 studies	27% ± 6%	Explore
CD8-positive, alpha-beta T cell	5 studies	25% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	31% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	32% ± 8%	Explore
CD4-positive helper T cell	3 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 5%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD28 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	351.66	567 / 578	81%	3.31	940 / 1155
breast	90%	198.99	415 / 459	80%	3.24	893 / 1118
intestine	68%	230.43	654 / 966	53%	1.49	280 / 527
prostate	58%	74.72	143 / 245	59%	1.74	298 / 502
stomach	53%	51.38	191 / 359	63%	2.04	181 / 286
kidney	47%	88.28	42 / 89	69%	2.55	622 / 901
bladder	67%	94.24	14 / 21	49%	1.41	247 / 504
skin	34%	34.09	609 / 1809	74%	3.67	350 / 472
thymus	55%	115.14	357 / 653	46%	2.80	276 / 605
spleen	100%	816.59	241 / 241	0%	0	0 / 0
adipose	98%	425.17	1181 / 1204	0%	0	0 / 0
peripheral blood	97%	1015.87	900 / 929	0%	0	0 / 0
liver	54%	52.79	121 / 226	42%	1.02	170 / 406
uterus	45%	41.39	77 / 170	50%	1.30	230 / 459
lymph node	0%	0	0 / 0	93%	18.72	27 / 29
esophagus	34%	36.49	493 / 1445	55%	1.63	101 / 183
tonsil	0%	0	0 / 0	78%	4.46	35 / 45
blood vessel	75%	228.77	1007 / 1335	0%	0	0 / 0
ovary	33%	30.26	59 / 180	37%	0.69	158 / 430
pancreas	2%	1.19	6 / 328	61%	2.39	109 / 178
adrenal gland	14%	9.38	36 / 258	21%	0.51	49 / 230
heart	33%	34.50	282 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	24%	0.59	19 / 80
brain	1%	0.86	27 / 2642	9%	0.21	60 / 705
muscle	8%	7.30	67 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0097190	Biological process	apoptotic signaling pathway
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0032753	Biological process	positive regulation of interleukin-4 production
GO_0010629	Biological process	negative regulation of gene expression
GO_0002863	Biological process	positive regulation of inflammatory response to antigenic stimulus
GO_0035739	Biological process	CD4-positive, alpha-beta T cell proliferation
GO_0031295	Biological process	T cell costimulation
GO_0010628	Biological process	positive regulation of gene expression
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0045070	Biological process	positive regulation of viral genome replication
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0006959	Biological process	humoral immune response
GO_0045066	Biological process	regulatory T cell differentiation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0048304	Biological process	positive regulation of isotype switching to IgG isotypes
GO_0045589	Biological process	regulation of regulatory T cell differentiation
GO_2000563	Biological process	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0045727	Biological process	positive regulation of translation
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0045060	Biological process	negative thymic T cell selection
GO_0001819	Biological process	positive regulation of cytokine production
GO_0042110	Biological process	T cell activation
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0001772	Cellular component	immunological synapse
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0098636	Cellular component	protein complex involved in cell adhesion
GO_0015026	Molecular function	coreceptor activity
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD28
Protein name	T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)
Synonyms
Description	FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation . Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells . .
Accessions	ENST00000374481.7 [P10747-2] P10747 ENST00000458610.6 [P10747-7] ENST00000324106.9 [P10747-1]

CD28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review