DAG1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	10 studies	24% ± 8%	Explore
endothelial cell	6 studies	22% ± 3%	Explore
epithelial cell	5 studies	30% ± 13%	Explore
type I pneumocyte	4 studies	23% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	28% ± 10%	Explore
podocyte	3 studies	38% ± 9%	Explore
placental villous trophoblast	3 studies	26% ± 7%	Explore
glial cell	3 studies	23% ± 5%	Explore
ciliated cell	3 studies	28% ± 8%	Explore
GABAergic neuron	3 studies	30% ± 7%	Explore
glutamatergic neuron	3 studies	36% ± 9%	Explore
abnormal cell	3 studies	26% ± 7%	Explore
Schwann cell	3 studies	22% ± 5%	Explore
goblet cell	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	7445.21	328 / 328	100%	100.11	178 / 178
intestine	100%	8741.89	966 / 966	100%	93.76	525 / 527
prostate	100%	6044.59	245 / 245	100%	88.89	500 / 502
breast	100%	5987.50	459 / 459	100%	114.88	1113 / 1118
lung	100%	6607.12	577 / 578	100%	82.92	1151 / 1155
ovary	99%	5781.80	179 / 180	100%	141.45	430 / 430
skin	100%	7499.81	1808 / 1809	99%	168.31	469 / 472
stomach	100%	6900.70	359 / 359	99%	115.51	283 / 286
uterus	100%	7430.95	170 / 170	99%	82.79	454 / 459
esophagus	100%	9390.25	1445 / 1445	99%	123.06	181 / 183
bladder	100%	7409.38	21 / 21	99%	85.53	498 / 504
liver	100%	4824.72	226 / 226	98%	64.94	397 / 406
kidney	100%	6633.78	89 / 89	97%	63.56	878 / 901
brain	98%	3983.62	2583 / 2642	100%	118.65	702 / 705
thymus	100%	5371.19	651 / 653	96%	69.23	582 / 605
adrenal gland	100%	5816.12	257 / 258	84%	34.07	193 / 230
adipose	100%	5454.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9904.07	1335 / 1335	0%	0	0 / 0
muscle	100%	13586.61	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	77.98	45 / 45
ureter	0%	0	0 / 0	100%	120.24	1 / 1
heart	99%	10047.89	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	68.41	79 / 80
spleen	97%	2532.61	234 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	10.93	14 / 29
peripheral blood	17%	384.95	158 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0021675	Biological process	nerve development
GO_0060055	Biological process	angiogenesis involved in wound healing
GO_0060441	Biological process	epithelial tube branching involved in lung morphogenesis
GO_0034453	Biological process	microtubule anchoring
GO_0016340	Biological process	calcium-dependent cell-matrix adhesion
GO_0031643	Biological process	positive regulation of myelination
GO_0016203	Biological process	muscle attachment
GO_0043434	Biological process	response to peptide hormone
GO_0014894	Biological process	response to denervation involved in regulation of muscle adaptation
GO_0043403	Biological process	skeletal muscle tissue regeneration
GO_0071711	Biological process	basement membrane organization
GO_0050807	Biological process	regulation of synapse organization
GO_0071397	Biological process	cellular response to cholesterol
GO_0030336	Biological process	negative regulation of cell migration
GO_0003007	Biological process	heart morphogenesis
GO_0031103	Biological process	axon regeneration
GO_0002009	Biological process	morphogenesis of an epithelium
GO_0098942	Biological process	retrograde trans-synaptic signaling by trans-synaptic protein complex
GO_0002011	Biological process	morphogenesis of an epithelial sheet
GO_0060445	Biological process	branching involved in salivary gland morphogenesis
GO_0021682	Biological process	nerve maturation
GO_0046718	Biological process	symbiont entry into host cell
GO_0016476	Biological process	regulation of embryonic cell shape
GO_0048714	Biological process	positive regulation of oligodendrocyte differentiation
GO_0098696	Biological process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0010717	Biological process	regulation of epithelial to mesenchymal transition
GO_0006509	Biological process	membrane protein ectodomain proteolysis
GO_0001954	Biological process	positive regulation of cell-matrix adhesion
GO_0010470	Biological process	regulation of gastrulation
GO_0014850	Biological process	response to muscle activity
GO_0022011	Biological process	myelination in peripheral nervous system
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0071679	Biological process	commissural neuron axon guidance
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0015031	Biological process	protein transport
GO_1904261	Biological process	positive regulation of basement membrane assembly involved in embryonic body morphogenesis
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0005856	Cellular component	cytoskeleton
GO_0044853	Cellular component	plasma membrane raft
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0098684	Cellular component	photoreceptor ribbon synapse
GO_0045211	Cellular component	postsynaptic membrane
GO_0016011	Cellular component	dystroglycan complex
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0098982	Cellular component	GABA-ergic synapse
GO_0030175	Cellular component	filopodium
GO_0005912	Cellular component	adherens junction
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030027	Cellular component	lamellipodium
GO_0034399	Cellular component	nuclear periphery
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043034	Cellular component	costamere
GO_0016010	Cellular component	dystrophin-associated glycoprotein complex
GO_0099524	Cellular component	postsynaptic cytosol
GO_0005737	Cellular component	cytoplasm
GO_0033268	Cellular component	node of Ranvier
GO_0005796	Cellular component	Golgi lumen
GO_0042383	Cellular component	sarcolemma
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005925	Cellular component	focal adhesion
GO_0070938	Cellular component	contractile ring
GO_0005829	Cellular component	cytosol
GO_0005604	Cellular component	basement membrane
GO_0002162	Molecular function	dystroglycan binding
GO_0001618	Molecular function	virus receptor activity
GO_0042169	Molecular function	SH2 domain binding
GO_0005509	Molecular function	calcium ion binding
GO_0008307	Molecular function	structural constituent of muscle
GO_0017166	Molecular function	vinculin binding
GO_0043236	Molecular function	laminin binding
GO_0003779	Molecular function	actin binding
GO_0051393	Molecular function	alpha-actinin binding
GO_0005515	Molecular function	protein binding
GO_0015631	Molecular function	tubulin binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0043237	Molecular function	laminin-1 binding

IV. Literature review

[source]

Gene name	DAG1
Protein name	Dystrophin Dystroglycan 1 Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
Synonyms
Description	FUNCTION: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). .; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses . Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 . .
Accessions	ENST00000308775.7 ENST00000435508.7 ENST00000697271.1 ENST00000421560.5 ENST00000431960.5 C9JEN1 ENST00000430636.1 ENST00000431960.6 ENST00000418588.6 C9JYS1 Q9UMK9 ENST00000469139.2 ENST00000421560.6 A0A1D5RMP6 Q14118 ENST00000428779.6 ENST00000466701.2 ENST00000452317.5 ENST00000469139.1 ENST00000452317.6 ENST00000428779.7 C9JY76 A0A669KB80 C9JEH2 ENST00000430636.2 ENST00000452060.7 ENST00000673708.1 ENST00000496474.2 C9J196 ENST00000418588.5 C9J6Z6 ENST00000452060.6 C9JQL4 ENST00000435508.8

DAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review