FGF8 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGF8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	83%	15.57	2205 / 2642	6%	0.12	40 / 705
adipose	72%	10.76	870 / 1204	0%	0	0 / 0
breast	65%	10.26	297 / 459	0%	0.01	4 / 1118
peripheral blood	63%	13.05	589 / 929	0%	0	0 / 0
lung	49%	3.40	284 / 578	9%	0.40	102 / 1155
spleen	56%	4.00	135 / 241	0%	0	0 / 0
blood vessel	53%	3.54	707 / 1335	0%	0	0 / 0
bladder	48%	3.19	10 / 21	3%	1.66	16 / 504
skin	42%	2.36	767 / 1809	0%	0.01	2 / 472
kidney	40%	2.47	36 / 89	1%	0.05	7 / 901
prostate	37%	1.84	91 / 245	1%	0.01	3 / 502
uterus	23%	1.31	39 / 170	13%	2.88	58 / 459
muscle	32%	2.06	257 / 803	0%	0	0 / 0
intestine	27%	1.41	258 / 966	4%	0.15	21 / 527
esophagus	26%	1.43	373 / 1445	3%	0.08	6 / 183
heart	24%	1.56	210 / 861	0%	0	0 / 0
stomach	19%	0.85	67 / 359	3%	0.09	10 / 286
ovary	19%	0.81	34 / 180	2%	0.31	10 / 430
lymph node	0%	0	0 / 0	21%	0.31	6 / 29
thymus	17%	0.81	114 / 653	1%	0.02	6 / 605
adrenal gland	6%	0.32	16 / 258	1%	1.53	2 / 230
pancreas	6%	0.22	19 / 328	1%	0.03	2 / 178
liver	4%	0.16	9 / 226	1%	0.36	4 / 406
tonsil	0%	0	0 / 0	4%	0.10	2 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001839	Biological process	neural plate morphogenesis
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0001974	Biological process	blood vessel remodeling
GO_0042476	Biological process	odontogenesis
GO_0001759	Biological process	organ induction
GO_0030916	Biological process	otic vesicle formation
GO_0140014	Biological process	mitotic nuclear division
GO_0001947	Biological process	heart looping
GO_0050918	Biological process	positive chemotaxis
GO_0001656	Biological process	metanephros development
GO_0021798	Biological process	forebrain dorsal/ventral pattern formation
GO_0030878	Biological process	thyroid gland development
GO_0060128	Biological process	corticotropin hormone secreting cell differentiation
GO_0023019	Biological process	signal transduction involved in regulation of gene expression
GO_0051402	Biological process	neuron apoptotic process
GO_0030334	Biological process	regulation of cell migration
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0090134	Biological process	cell migration involved in mesendoderm migration
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0006979	Biological process	response to oxidative stress
GO_0048853	Biological process	forebrain morphogenesis
GO_0060037	Biological process	pharyngeal system development
GO_0021543	Biological process	pallium development
GO_0072089	Biological process	stem cell proliferation
GO_0051781	Biological process	positive regulation of cell division
GO_0008406	Biological process	gonad development
GO_0021846	Biological process	cell proliferation in forebrain
GO_0000165	Biological process	MAPK cascade
GO_0010628	Biological process	positive regulation of gene expression
GO_0007369	Biological process	gastrulation
GO_0021544	Biological process	subpallium development
GO_0120223	Biological process	larynx morphogenesis
GO_0030182	Biological process	neuron differentiation
GO_0001823	Biological process	mesonephros development
GO_0008078	Biological process	mesodermal cell migration
GO_0045165	Biological process	cell fate commitment
GO_0060425	Biological process	lung morphogenesis
GO_0042487	Biological process	regulation of odontogenesis of dentin-containing tooth
GO_0021884	Biological process	forebrain neuron development
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0060348	Biological process	bone development
GO_0033563	Biological process	dorsal/ventral axon guidance
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0035265	Biological process	organ growth
GO_0055026	Biological process	negative regulation of cardiac muscle tissue development
GO_0003198	Biological process	epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0060445	Biological process	branching involved in salivary gland morphogenesis
GO_0009887	Biological process	animal organ morphogenesis
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0060129	Biological process	thyroid-stimulating hormone-secreting cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0046622	Biological process	positive regulation of organ growth
GO_0014070	Biological process	response to organic cyclic compound
GO_2000648	Biological process	positive regulation of stem cell proliferation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0030917	Biological process	midbrain-hindbrain boundary development
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0045745	Biological process	positive regulation of G protein-coupled receptor signaling pathway
GO_0009953	Biological process	dorsal/ventral pattern formation
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0030539	Biological process	male genitalia development
GO_0060563	Biological process	neuroepithelial cell differentiation
GO_0035909	Biological process	aorta morphogenesis
GO_0048702	Biological process	embryonic neurocranium morphogenesis
GO_0008045	Biological process	motor neuron axon guidance
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0005576	Cellular component	extracellular region
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0042056	Molecular function	chemoattractant activity
GO_0005105	Molecular function	type 1 fibroblast growth factor receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0005111	Molecular function	type 2 fibroblast growth factor receptor binding

Gene name	FGF8
Protein name	Fibroblast growth factor 8 (FGF-8) (Androgen-induced growth factor) (AIGF) (Heparin-binding growth factor 8) (HBGF-8) Fibroblast growth factor (FGF) Fibroblast growth factor 8
Synonyms	hCG_25633 AIGF
Description	FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system . Plays a role in neurite outgrowth in hippocampal cells . .
Accessions	A0A087X1S5 ENST00000346714.7 [P55075-2] ENST00000618991.5 ENST00000469792.6 ENST00000320185.7 [P55075-4] R4GMQ3 ENST00000347978.2 [P55075-3] A1A515 P55075 A0A0S1MI72 ENST00000344255.8 [P55075-1]

FGF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review