PDCD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDCD1 at tissue level.

III. Associated gene sets

GO_1902482Biological processregulatory T cell apoptotic process
GO_0006915Biological processapoptotic process
GO_0002250Biological processadaptive immune response
GO_0050868Biological processnegative regulation of T cell activation
GO_0002644Biological processnegative regulation of tolerance induction
GO_0002903Biological processnegative regulation of B cell apoptotic process
GO_0050777Biological processnegative regulation of immune response
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0070234Biological processpositive regulation of T cell apoptotic process
GO_0050776Biological processregulation of immune response
GO_0001783Biological processB cell apoptotic process
GO_0006959Biological processhumoral immune response
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDCD1
Protein nameProgrammed cell death 1 (Programmed cell death protein 1)
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Programmed cell death 1 protein
SynonymsPD1
DescriptionFUNCTION: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self . Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 . Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). .; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival . The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function . The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy . .

AccessionsE7ER21
A0A0M3M0G7
ENST00000630230.1
Q15116
ENST00000334409.10
ENST00000343705.3
ENST00000630560.1
H0Y2W6
ENST00000418831.1
ENST00000618185.3