ITGAV | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	30% ± 10%	Explore
fibroblast	23 studies	26% ± 7%	Explore
astrocyte	19 studies	43% ± 16%	Explore
oligodendrocyte precursor cell	15 studies	40% ± 17%	Explore
macrophage	14 studies	28% ± 9%	Explore
smooth muscle cell	13 studies	23% ± 7%	Explore
oligodendrocyte	13 studies	29% ± 9%	Explore
pericyte	11 studies	23% ± 5%	Explore
microglial cell	11 studies	35% ± 12%	Explore
basal cell	9 studies	27% ± 18%	Explore
epithelial cell	8 studies	37% ± 18%	Explore
endothelial cell of artery	8 studies	25% ± 9%	Explore
adipocyte	7 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	6 studies	33% ± 10%	Explore
myeloid cell	6 studies	22% ± 4%	Explore
retinal cone cell	6 studies	26% ± 9%	Explore
vein endothelial cell	6 studies	31% ± 16%	Explore
Mueller cell	6 studies	35% ± 14%	Explore
type I pneumocyte	6 studies	21% ± 6%	Explore
connective tissue cell	6 studies	27% ± 9%	Explore
GABAergic neuron	5 studies	35% ± 12%	Explore
retinal bipolar neuron	5 studies	31% ± 6%	Explore
retinal pigment epithelial cell	5 studies	77% ± 12%	Explore
cardiac muscle cell	5 studies	39% ± 12%	Explore
retinal rod cell	5 studies	25% ± 6%	Explore
capillary endothelial cell	5 studies	26% ± 9%	Explore
monocyte	4 studies	17% ± 2%	Explore
club cell	4 studies	17% ± 1%	Explore
ciliated cell	4 studies	29% ± 10%	Explore
lymphocyte	4 studies	20% ± 4%	Explore
myofibroblast cell	4 studies	26% ± 6%	Explore
endothelial cell of vascular tree	4 studies	31% ± 18%	Explore
luminal cell of prostate epithelium	4 studies	21% ± 4%	Explore
pancreatic A cell	3 studies	29% ± 7%	Explore
glial cell	3 studies	22% ± 1%	Explore
mononuclear phagocyte	3 studies	21% ± 2%	Explore
ON-bipolar cell	3 studies	38% ± 14%	Explore
rod bipolar cell	3 studies	64% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	26% ± 11%	Explore
muscle cell	3 studies	30% ± 15%	Explore
glutamatergic neuron	3 studies	39% ± 4%	Explore
pancreatic ductal cell	3 studies	48% ± 23%	Explore
adventitial cell	3 studies	21% ± 6%	Explore
alveolar macrophage	3 studies	27% ± 8%	Explore
granule cell	3 studies	17% ± 1%	Explore
interneuron	3 studies	34% ± 9%	Explore
podocyte	3 studies	73% ± 4%	Explore
renal alpha-intercalated cell	3 studies	32% ± 6%	Explore
renal principal cell	3 studies	28% ± 8%	Explore
secretory cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	28% ± 11%	Explore
eye	8 studies	28% ± 12%	Explore
lung	6 studies	21% ± 4%	Explore
heart	4 studies	27% ± 7%	Explore
pancreas	3 studies	34% ± 11%	Explore
uterus	3 studies	22% ± 9%	Explore
adipose	3 studies	19% ± 2%	Explore
kidney	3 studies	22% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	99%	5721.62	1437 / 1445	100%	109.85	183 / 183
brain	99%	5502.18	2627 / 2642	99%	114.85	701 / 705
lung	100%	8497.16	576 / 578	99%	88.62	1138 / 1155
breast	100%	6280.90	459 / 459	98%	82.43	1092 / 1118
thymus	100%	8284.45	653 / 653	96%	104.83	583 / 605
kidney	100%	7529.18	89 / 89	96%	103.96	861 / 901
prostate	100%	5093.48	244 / 245	96%	54.65	481 / 502
pancreas	98%	3452.80	321 / 328	97%	89.00	173 / 178
uterus	100%	8580.10	170 / 170	94%	57.29	432 / 459
stomach	99%	4807.28	356 / 359	93%	53.04	266 / 286
bladder	100%	6224.81	21 / 21	89%	49.31	448 / 504
intestine	100%	5149.09	964 / 966	89%	44.31	468 / 527
ovary	100%	8883.26	180 / 180	88%	39.97	378 / 430
skin	100%	8039.11	1804 / 1809	85%	52.87	401 / 472
adrenal gland	100%	8090.86	258 / 258	75%	30.30	172 / 230
liver	54%	1308.53	121 / 226	55%	29.16	225 / 406
adipose	100%	7171.55	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13711.62	1335 / 1335	0%	0	0 / 0
spleen	100%	3564.54	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	21.64	1 / 1
tonsil	0%	0	0 / 0	98%	90.13	44 / 45
muscle	97%	3151.33	782 / 803	0%	0	0 / 0
heart	96%	8699.71	825 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	48%	11.73	14 / 29
eye	0%	0	0 / 0	41%	12.61	33 / 80
peripheral blood	17%	358.37	158 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_0031589	Biological process	cell-substrate adhesion
GO_2000536	Biological process	negative regulation of entry of bacterium into host cell
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0033690	Biological process	positive regulation of osteoblast proliferation
GO_0007160	Biological process	cell-matrix adhesion
GO_0035987	Biological process	endodermal cell differentiation
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0001570	Biological process	vasculogenesis
GO_1902533	Biological process	positive regulation of intracellular signal transduction
GO_0007155	Biological process	cell adhesion
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_1905598	Biological process	negative regulation of low-density lipoprotein receptor activity
GO_0050919	Biological process	negative chemotaxis
GO_0010745	Biological process	negative regulation of macrophage derived foam cell differentiation
GO_0032369	Biological process	negative regulation of lipid transport
GO_0046718	Biological process	symbiont entry into host cell
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0043277	Biological process	apoptotic cell clearance
GO_0030335	Biological process	positive regulation of cell migration
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0038027	Biological process	apolipoprotein A-I-mediated signaling pathway
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0051057	Biological process	positive regulation of small GTPase mediated signal transduction
GO_0085017	Biological process	entry into host cell by a symbiont-containing vacuole
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0050764	Biological process	regulation of phagocytosis
GO_0050748	Biological process	negative regulation of lipoprotein metabolic process
GO_0010888	Biological process	negative regulation of lipid storage
GO_0098609	Biological process	cell-cell adhesion
GO_0035313	Biological process	wound healing, spreading of epidermal cells
GO_0016477	Biological process	cell migration
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0071604	Biological process	transforming growth factor beta production
GO_0032587	Cellular component	ruffle membrane
GO_0034683	Cellular component	integrin alphav-beta3 complex
GO_0009897	Cellular component	external side of plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0031528	Cellular component	microvillus membrane
GO_0008305	Cellular component	integrin complex
GO_0070062	Cellular component	extracellular exosome
GO_0035866	Cellular component	alphav-beta3 integrin-PKCalpha complex
GO_0005925	Cellular component	focal adhesion
GO_0031527	Cellular component	filopodium membrane
GO_0009986	Cellular component	cell surface
GO_0034686	Cellular component	integrin alphav-beta8 complex
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0045335	Cellular component	phagocytic vesicle
GO_0035867	Cellular component	alphav-beta3 integrin-IGF-1-IGF1R complex
GO_0034682	Cellular component	integrin alphav-beta1 complex
GO_0034684	Cellular component	integrin alphav-beta5 complex
GO_0035868	Cellular component	alphav-beta3 integrin-HMGB1 complex
GO_0034685	Cellular component	integrin alphav-beta6 complex
GO_0005080	Molecular function	protein kinase C binding
GO_1990430	Molecular function	extracellular matrix protein binding
GO_0015026	Molecular function	coreceptor activity
GO_0019960	Molecular function	C-X3-C chemokine binding
GO_0001968	Molecular function	fibronectin binding
GO_0001618	Molecular function	virus receptor activity
GO_0031994	Molecular function	insulin-like growth factor I binding
GO_0005178	Molecular function	integrin binding
GO_0002020	Molecular function	protease binding
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0005245	Molecular function	voltage-gated calcium channel activity
GO_0046872	Molecular function	metal ion binding
GO_0001846	Molecular function	opsonin binding
GO_0050840	Molecular function	extracellular matrix binding
GO_0038132	Molecular function	neuregulin binding
GO_0017134	Molecular function	fibroblast growth factor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGAV
Protein name	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] ITGAV protein Integrin, alpha V Integrin subunit alpha V
Synonyms	VTNR VNRA MSK8
Description	FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling . ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 . Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation . ITGAV:ITGB3 acts as a receptor for CD40LG . ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP . .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. .
Accessions	ENST00000696914.1 ENST00000696907.1 A0A8V8TKH9 ENST00000261023.8 [P06756-1] A5YM53 ENST00000696937.1 ENST00000696906.1 ENST00000696912.1 A0A8V8TLN8 ENST00000696909.1 ENST00000433736.6 [P06756-3] ENST00000696908.1 ENST00000696910.1 A0A8V8TKI2 L7RXH0 A0A8V8TKF7 P06756 ENST00000696911.1 A0A8V8TKU8 A0A8V8TKG0 A0A8V8TLW4 ENST00000696913.1 H7BZG1 ENST00000374907.7 [P06756-2] ENST00000430709.1 A0A8V8TLP3 A0A8V8TKT8 A0A8V8TLW9

ITGAV report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review