IL13 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL13 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL13 at tissue level.

III. Associated gene sets

GO_0043306Biological processpositive regulation of mast cell degranulation
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0042116Biological processmacrophage activation
GO_1901247Biological processnegative regulation of lung ciliated cell differentiation
GO_0006954Biological processinflammatory response
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0001774Biological processmicroglial cell activation
GO_0071260Biological processcellular response to mechanical stimulus
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0045471Biological processresponse to ethanol
GO_0032723Biological processpositive regulation of connective tissue growth factor production
GO_0043032Biological processpositive regulation of macrophage activation
GO_0006955Biological processimmune response
GO_0050714Biological processpositive regulation of protein secretion
GO_0071635Biological processnegative regulation of transforming growth factor beta production
GO_0071345Biological processcellular response to cytokine stimulus
GO_0050728Biological processnegative regulation of inflammatory response
GO_2000231Biological processpositive regulation of pancreatic stellate cell proliferation
GO_1901251Biological processpositive regulation of lung goblet cell differentiation
GO_1903660Biological processnegative regulation of complement-dependent cytotoxicity
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0035094Biological processresponse to nicotine
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0010155Biological processregulation of proton transport
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005144Molecular functioninterleukin-13 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL13
Protein nameInterleukin-13
Interleukin-13 (IL-13)
SynonymsNC30
DescriptionFUNCTION: Cytokine that plays important roles in allergic inflammation and immune response to parasite infection . Synergizes with IL2 in regulating interferon-gamma synthesis . Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells . Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils . Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 . Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 . .

AccessionsENST00000304506.7
Q4VB53
Q4VB50
Q4VB51
P35225