IL12B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL12B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL12B at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_0051135Biological processpositive regulation of NK T cell activation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0010536Biological processpositive regulation of activation of Janus kinase activity
GO_1903588Biological processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0042098Biological processT cell proliferation
GO_0043382Biological processpositive regulation of memory T cell differentiation
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0042832Biological processdefense response to protozoan
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0032946Biological processpositive regulation of mononuclear cell proliferation
GO_0051607Biological processdefense response to virus
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0030101Biological processnatural killer cell activation
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0045785Biological processpositive regulation of cell adhesion
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0034105Biological processpositive regulation of tissue remodeling
GO_0050709Biological processnegative regulation of protein secretion
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0001916Biological processpositive regulation of T cell mediated cytotoxicity
GO_0010224Biological processresponse to UV-B
GO_0034393Biological processpositive regulation of smooth muscle cell apoptotic process
GO_0042093Biological processT-helper cell differentiation
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0042088Biological processT-helper 1 type immune response
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0051142Biological processpositive regulation of NK T cell proliferation
GO_0050671Biological processpositive regulation of lymphocyte proliferation
GO_0032816Biological processpositive regulation of natural killer cell activation
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0001817Biological processregulation of cytokine production
GO_0019953Biological processsexual reproduction
GO_0035722Biological processinterleukin-12-mediated signaling pathway
GO_1900747Biological processnegative regulation of vascular endothelial growth factor signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002860Biological processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0032729Biological processpositive regulation of type II interferon production
GO_0050729Biological processpositive regulation of inflammatory response
GO_0002827Biological processpositive regulation of T-helper 1 type immune response
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0002323Biological processnatural killer cell activation involved in immune response
GO_0016477Biological processcell migration
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0042509Biological processregulation of tyrosine phosphorylation of STAT protein
GO_0071346Biological processcellular response to type II interferon
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0070743Cellular componentinterleukin-23 complex
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0031906Cellular componentlate endosome lumen
GO_0043514Cellular componentinterleukin-12 complex
GO_0045519Molecular functioninterleukin-23 receptor binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019955Molecular functioncytokine binding
GO_0042802Molecular functionidentical protein binding
GO_0042164Molecular functioninterleukin-12 alpha subunit binding
GO_0008083Molecular functiongrowth factor activity
GO_0004896Molecular functioncytokine receptor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005143Molecular functioninterleukin-12 receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL12B
Protein nameInterleukin 12B
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Truncated interleukin 12B
SynonymsNKSF2
DescriptionFUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. .; FUNCTION: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. .

AccessionsA0A0C5Q0C2
P29460
ENST00000231228.3
ENST00000696751.1
A0A0C5PSA9
A0A0C5PS98
A0A8Q3SJ12
A0A0C5PMG4
A0A0C5PF30
A0A8Q3WML5
ENST00000696750.1
A0A0C5PP88
A0A0C5PF35
A0A0C5Q0B8
A0A0C5PP83
A0A0C5Q0C7