interleukin-12 complex

I. Literature review

[source]
Nameinterleukin-12 complex
IDGO_0043514
collection_id

Cellular component

Exact synonym

IL-12 complex

Description

A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.

Comment

Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.

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Genes