TRPM8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRPM8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRPM8 at tissue level.

III. Associated gene sets

GO_0006874Biological processintracellular calcium ion homeostasis
GO_0009409Biological processresponse to cold
GO_0019722Biological processcalcium-mediated signaling
GO_0070588Biological processcalcium ion transmembrane transport
GO_0050955Biological processthermoception
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045121Cellular componentmembrane raft
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0099604Molecular functionligand-gated calcium channel activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTRPM8
Protein nameTransient receptor melastatin 8 variant 31
Transient receptor melastatin 8 variant 15
Transient receptor melastatin 8 variant 22
Transient receptor melastatin 8 variant 20 (Transient receptor melastatin 8 variant 23)
TRPM8 isoform 51kDa channel protein (TRPM8 isoform, 40kDa channel protein)
Transient receptor melastatin 8 variant 10
Transient receptor melastatin 8 variant 11
Transient receptor melastatin 8 variant 28
Transient receptor melastatin 8 variant 16
Transient receptor melastatin 8 variant 4 (Transient receptor melastatin 8 variant 6)
Transient receptor melastatin 8 variant 12
Transient receptor melastatin 8 variant 13 (Transient receptor melastatin 8 variant 18)
Transient receptor melastatin 8 variant 14
Transient receptor melastatin 8 variant 19
Transient receptor melastatin 8 variant 17
Transient receptor melastatin 8 variant 33
Transient receptor melastatin 8 variant 3
TRPM8
Transient receptor melastatin 8 variant 21
Transient receptor potential cation channel subfamily M member 8
Transient receptor melastatin 8 variant 25
Transient receptor melastatin 8 variant 26
Transient receptor melastatin 8 variant 30
Transient receptor melastatin 8 variant 29 isoform 27kDa (Transient receptor melastatin 8 variant 32 isoform 27kDa) (Transient receptor melastatin 8 variant 34)
Transient receptor melastatin 8 variant 24
Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)
Transient receptor melastatin 8 variant 29 isoform 35kDa (Transient receptor melastatin 8 variant 32 isoform 35kDa)
Transient receptor melastatin 8
Transient receptor melastatin 8 variant 5 (Transient receptor melastatin 8 variant 8)
Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential cation channel, subfamily M, member 8, isoform CRA_a)
SynonymsLTRPC6
hCG_2012695
TRPP8
DescriptionFUNCTION: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration . Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. .

AccessionsA0A1L1Z865
ENST00000456930.1
A0A1L1Z866
A0A0C4DFT0
A0A1L1Z852
A0A1L1Z861
A0A1L1Z869
A0A1L1Z860
C4P721
H7BZP4
W8DTH1
ENST00000355722.8
A0A1L1Z843
A0A1L1Z868
A0A1L1Z878
A0A1L1Z853
A0A1L1Z822
ENST00000433712.6
A0A1L1Z836
A0A0A0MSV2
ENST00000444298.5
A0A1L1Z839
F8WD55
ENST00000324695.9 [Q7Z2W7-1]
A0A1L1Z857
A0A1L1Z830
A0A1L1Z847
A0A0B4L3I6
A0A1L1Z848
A0A1L1Z856
A0A1L1Z834
Q7Z2W7
ENST00000409625.1 [Q7Z2W7-3]
A0A1L1Z855
A0A1L1Z846
A0A1L1Z867
A0A1L1Z877
ENST00000439148.1
A0A1L1Z859
H0Y7P0