CD59 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	49 studies	60% ± 25%	Explore
fibroblast	39 studies	48% ± 19%	Explore
pericyte	35 studies	56% ± 23%	Explore
macrophage	32 studies	30% ± 13%	Explore
endothelial cell of lymphatic vessel	30 studies	70% ± 26%	Explore
smooth muscle cell	24 studies	49% ± 20%	Explore
basal cell	21 studies	54% ± 26%	Explore
ciliated cell	19 studies	73% ± 18%	Explore
epithelial cell	17 studies	55% ± 25%	Explore
connective tissue cell	17 studies	44% ± 20%	Explore
vein endothelial cell	16 studies	60% ± 23%	Explore
mast cell	15 studies	28% ± 7%	Explore
plasma cell	15 studies	46% ± 22%	Explore
endothelial cell of artery	15 studies	57% ± 23%	Explore
capillary endothelial cell	15 studies	63% ± 20%	Explore
regulatory T cell	15 studies	23% ± 8%	Explore
endothelial cell of vascular tree	15 studies	72% ± 26%	Explore
astrocyte	12 studies	33% ± 15%	Explore
conventional dendritic cell	12 studies	21% ± 4%	Explore
secretory cell	11 studies	65% ± 22%	Explore
myofibroblast cell	11 studies	44% ± 18%	Explore
myeloid cell	9 studies	28% ± 11%	Explore
type II pneumocyte	8 studies	66% ± 23%	Explore
type I pneumocyte	7 studies	61% ± 12%	Explore
plasmablast	7 studies	38% ± 23%	Explore
club cell	7 studies	48% ± 22%	Explore
ionocyte	7 studies	62% ± 13%	Explore
T cell	7 studies	28% ± 12%	Explore
oligodendrocyte precursor cell	7 studies	29% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	33% ± 9%	Explore
abnormal cell	7 studies	38% ± 18%	Explore
goblet cell	7 studies	32% ± 18%	Explore
respiratory goblet cell	6 studies	47% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	60% ± 19%	Explore
renal alpha-intercalated cell	6 studies	68% ± 21%	Explore
mesothelial cell	6 studies	42% ± 21%	Explore
glial cell	6 studies	46% ± 20%	Explore
melanocyte	6 studies	73% ± 21%	Explore
alveolar macrophage	5 studies	38% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	47% ± 21%	Explore
microglial cell	5 studies	27% ± 7%	Explore
innate lymphoid cell	5 studies	25% ± 7%	Explore
keratinocyte	5 studies	28% ± 11%	Explore
dendritic cell	5 studies	34% ± 14%	Explore
CD4-positive, alpha-beta T cell	5 studies	27% ± 10%	Explore
deuterosomal cell	4 studies	32% ± 4%	Explore
duct epithelial cell	4 studies	76% ± 16%	Explore
squamous epithelial cell	4 studies	68% ± 8%	Explore
pancreatic A cell	4 studies	74% ± 16%	Explore
type B pancreatic cell	4 studies	52% ± 22%	Explore
GABAergic neuron	4 studies	34% ± 9%	Explore
glomerular endothelial cell	4 studies	40% ± 10%	Explore
podocyte	4 studies	78% ± 9%	Explore
IgG plasma cell	4 studies	19% ± 3%	Explore
retinal ganglion cell	4 studies	73% ± 24%	Explore
natural killer cell	4 studies	29% ± 6%	Explore
retina horizontal cell	4 studies	24% ± 9%	Explore
monocyte	4 studies	27% ± 9%	Explore
adventitial cell	4 studies	54% ± 22%	Explore
mucus secreting cell	4 studies	66% ± 10%	Explore
Mueller cell	4 studies	44% ± 19%	Explore
Schwann cell	4 studies	48% ± 26%	Explore
erythroblast	4 studies	35% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	78% ± 9%	Explore
neuron	4 studies	40% ± 13%	Explore
luminal cell of prostate epithelium	4 studies	54% ± 22%	Explore
glutamatergic neuron	4 studies	37% ± 18%	Explore
enteroendocrine cell	4 studies	33% ± 18%	Explore
hillock cell	3 studies	39% ± 11%	Explore
pancreatic D cell	3 studies	70% ± 19%	Explore
classical monocyte	3 studies	18% ± 0%	Explore
renal principal cell	3 studies	53% ± 7%	Explore
extravillous trophoblast	3 studies	67% ± 2%	Explore
placental villous trophoblast	3 studies	86% ± 3%	Explore
neuroendocrine cell	3 studies	64% ± 10%	Explore
amacrine cell	3 studies	29% ± 10%	Explore
serous secreting cell	3 studies	63% ± 21%	Explore
lymphocyte	3 studies	73% ± 24%	Explore
B cell	3 studies	18% ± 0%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	21% ± 3%	Explore
chondrocyte	3 studies	34% ± 23%	Explore
endothelial cell of sinusoid	3 studies	53% ± 22%	Explore
erythrocyte	3 studies	32% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 13%	Explore
myoepithelial cell	3 studies	57% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
pancreatic ductal cell	3 studies	93% ± 3%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
leukocyte	3 studies	29% ± 3%	Explore
hepatocyte	3 studies	40% ± 22%	Explore
mononuclear phagocyte	3 studies	38% ± 6%	Explore
interneuron	3 studies	30% ± 12%	Explore
hematopoietic stem cell	3 studies	22% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	70% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	42% ± 17%	Explore
brain	9 studies	28% ± 7%	Explore
kidney	9 studies	32% ± 16%	Explore
intestine	7 studies	23% ± 11%	Explore
eye	7 studies	31% ± 12%	Explore
heart	5 studies	21% ± 3%	Explore
uterus	5 studies	50% ± 10%	Explore
prostate	5 studies	60% ± 26%	Explore
pancreas	4 studies	66% ± 18%	Explore
placenta	4 studies	59% ± 22%	Explore
skin	4 studies	37% ± 10%	Explore
liver	4 studies	31% ± 20%	Explore
breast	4 studies	56% ± 15%	Explore
adipose	3 studies	19% ± 2%	Explore
esophagus	3 studies	45% ± 15%	Explore
thymus	3 studies	27% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	22054.08	89 / 89	100%	150.30	901 / 901
thymus	100%	23306.46	653 / 653	100%	126.18	605 / 605
breast	100%	36092.25	459 / 459	100%	117.41	1114 / 1118
skin	100%	29491.25	1809 / 1809	100%	202.05	470 / 472
prostate	100%	15957.88	244 / 245	100%	60.05	501 / 502
adrenal gland	100%	16798.39	258 / 258	99%	90.61	228 / 230
uterus	100%	17827.39	170 / 170	99%	68.02	454 / 459
brain	99%	13323.42	2604 / 2642	100%	71.28	705 / 705
esophagus	100%	22509.91	1445 / 1445	98%	64.29	180 / 183
bladder	100%	20090.57	21 / 21	98%	66.34	494 / 504
lung	100%	38358.15	578 / 578	98%	78.74	1132 / 1155
intestine	100%	15939.74	965 / 966	96%	47.50	505 / 527
pancreas	94%	8411.70	307 / 328	100%	142.05	178 / 178
ovary	100%	11870.71	180 / 180	93%	39.46	402 / 430
stomach	100%	17095.59	359 / 359	93%	41.75	267 / 286
liver	73%	6004.27	166 / 226	97%	58.90	392 / 406
adipose	100%	34503.80	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	149.22	80 / 80
muscle	100%	19426.17	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	76.49	45 / 45
ureter	0%	0	0 / 0	100%	41.48	1 / 1
blood vessel	100%	27546.35	1334 / 1335	0%	0	0 / 0
heart	99%	24638.53	856 / 861	0%	0	0 / 0
spleen	97%	8584.85	233 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	32.92	28 / 29
peripheral blood	55%	5485.74	508 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030449	Biological process	regulation of complement activation
GO_0001971	Biological process	negative regulation of activation of membrane attack complex
GO_0007596	Biological process	blood coagulation
GO_1903659	Biological process	regulation of complement-dependent cytotoxicity
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0070821	Cellular component	tertiary granule membrane
GO_0030133	Cellular component	transport vesicle
GO_0012507	Cellular component	ER to Golgi transport vesicle membrane
GO_0031982	Cellular component	vesicle
GO_0001848	Molecular function	complement binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD59
Protein name	CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) CD59 blood group antigen variant CD59 glycoprotein (MAC-inhibitory protein) (Membrane attack complex inhibition factor) (Protectin) CD59 molecule (CD59 blood group) CD59 blood group antigen
Synonyms	MSK21 hCG_2033390 MIN2 MIC11 MIN1 MIN3
Description	FUNCTION: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Accessions	ENST00000528700.2 A0A499FJN7 ENST00000533403.6 ENST00000651485.1 A0A494C059 Q6FHM9 A0A9L9PXZ4 ENST00000437761.6 [P13987-1] A0A3G2LMJ8 ENST00000527577.5 [P13987-1] ENST00000415002.7 [P13987-1] ENST00000351554.8 [P13987-1] A0A2U3TZL5 ENST00000445143.6 [P13987-1] ENST00000652678.1 [P13987-1] ENST00000426650.7 ENST00000652086.1 ENST00000642928.2 [P13987-1] P13987 ENST00000706436.1 A0A3Q8TLE1 ENST00000651785.1 [P13987-1] A0A494C0W4 ENST00000395850.9 [P13987-1] ENST00000643183.1 E9PI80

CD59 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review