SLAMF1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLAMF1 at tissue level.

III. Associated gene sets

GO_2000349Biological processnegative regulation of CD40 signaling pathway
GO_0002277Biological processmyeloid dendritic cell activation involved in immune response
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_2000556Biological processpositive regulation of T-helper 1 cell cytokine production
GO_0002725Biological processnegative regulation of T cell cytokine production
GO_0031338Biological processregulation of vesicle fusion
GO_0001779Biological processnatural killer cell differentiation
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0007155Biological processcell adhesion
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0002250Biological processadaptive immune response
GO_2000510Biological processpositive regulation of dendritic cell chemotaxis
GO_0046718Biological processsymbiont entry into host cell
GO_0001787Biological processnatural killer cell proliferation
GO_0006909Biological processphagocytosis
GO_0032689Biological processnegative regulation of type II interferon production
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0002232Biological processleukocyte chemotaxis involved in inflammatory response
GO_0032729Biological processpositive regulation of type II interferon production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0045335Cellular componentphagocytic vesicle
GO_0038023Molecular functionsignaling receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0001618Molecular functionvirus receptor activity
GO_0042169Molecular functionSH2 domain binding
GO_0098631Molecular functioncell adhesion mediator activity
GO_0003823Molecular functionantigen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLAMF1
Protein nameSignaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
SynonymsSLAM
DescriptionFUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 . However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 . Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells . May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 . In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes . .; FUNCTION: (Microbial infection) Acts as a receptor for Measles virus; also including isoform 4. .

AccessionsENST00000538290.2 [Q13291-4]
Q13291
ENST00000302035.11 [Q13291-1]