ABCG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090181Biological processregulation of cholesterol metabolic process
GO_0055091Biological processphospholipid homeostasis
GO_0034436Biological processglycoprotein transport
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0055085Biological processtransmembrane transport
GO_0071403Biological processcellular response to high density lipoprotein particle stimulus
GO_0008203Biological processcholesterol metabolic process
GO_0043691Biological processreverse cholesterol transport
GO_0032367Biological processintracellular cholesterol transport
GO_0033700Biological processphospholipid efflux
GO_0034375Biological processhigh-density lipoprotein particle remodeling
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0050714Biological processpositive regulation of protein secretion
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0033993Biological processresponse to lipid
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0034204Biological processlipid translocation
GO_0033344Biological processcholesterol efflux
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0045542Biological processpositive regulation of cholesterol biosynthetic process
GO_0042632Biological processcholesterol homeostasis
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0055037Cellular componentrecycling endosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005768Cellular componentendosome
GO_0042803Molecular functionprotein homodimerization activity
GO_0043531Molecular functionADP binding
GO_0090554Molecular functionphosphatidylcholine floppase activity
GO_0015485Molecular functioncholesterol binding
GO_0005543Molecular functionphospholipid binding
GO_0120020Molecular functioncholesterol transfer activity
GO_0019534Molecular functiontoxin transmembrane transporter activity
GO_0140328Molecular functionfloppase activity
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0034041Molecular functionABC-type sterol transporter activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCG1
Protein nameATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog)
ATP binding cassette subfamily G member 1
SynonymsWHT1
ABC8
DescriptionFUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP . The lipid efflux is ALB-dependent . Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol . .

AccessionsP45844
ENST00000347800.6 [P45844-5]
ENST00000398449.8 [P45844-4]
ENST00000398457.6 [P45844-3]
ENST00000343687.7 [P45844-2]
C9JKD9
ENST00000361802.6 [P45844-1]
E9PGV9
ENST00000398437.1
ENST00000450121.5