ITGA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0033627Biological processcell adhesion mediated by integrin
GO_0045123Biological processcellular extravasation
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0007160Biological processcell-matrix adhesion
GO_0030593Biological processneutrophil chemotaxis
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0048812Biological processneuron projection morphogenesis
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0032516Biological processpositive regulation of phosphoprotein phosphatase activity
GO_0042311Biological processvasodilation
GO_0098609Biological processcell-cell adhesion
GO_0045178Cellular componentbasal part of cell
GO_0009897Cellular componentexternal side of plasma membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0008305Cellular componentintegrin complex
GO_0070062Cellular componentextracellular exosome
GO_0034665Cellular componentintegrin alpha1-beta1 complex
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0019903Molecular functionprotein phosphatase binding
GO_0098639Molecular functioncollagen binding involved in cell-matrix adhesion
GO_0005178Molecular functionintegrin binding
GO_0046872Molecular functionmetal ion binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameITGA1
Protein nameIntegrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)
Integrin subunit alpha 1
Synonyms
DescriptionFUNCTION: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. .

AccessionsENST00000282588.7
P56199
A0A494C0F7
ENST00000650673.1