EPHA5 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	54% ± 21%	Explore
GABAergic neuron	11 studies	45% ± 20%	Explore
oligodendrocyte precursor cell	7 studies	29% ± 10%	Explore
interneuron	6 studies	46% ± 20%	Explore
retinal ganglion cell	5 studies	48% ± 31%	Explore
neuron	4 studies	37% ± 10%	Explore
astrocyte	4 studies	31% ± 21%	Explore
endothelial cell	3 studies	40% ± 13%	Explore
GABAergic interneuron	3 studies	27% ± 8%	Explore
microglial cell	3 studies	35% ± 14%	Explore
glycinergic amacrine cell	3 studies	27% ± 7%	Explore
amacrine cell	3 studies	47% ± 24%	Explore
neural progenitor cell	3 studies	42% ± 31%	Explore

Name	Number of supported studies	Average coverage
brain	13 studies	39% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	616.12	2482 / 2642	65%	3.04	458 / 705
prostate	84%	192.41	205 / 245	49%	1.80	248 / 502
thymus	96%	219.09	625 / 653	9%	0.34	52 / 605
ovary	83%	168.48	149 / 180	0%	0.00	1 / 430
stomach	66%	76.49	236 / 359	1%	0.01	3 / 286
skin	12%	7.34	211 / 1809	46%	1.65	216 / 472
bladder	48%	57.10	10 / 21	1%	0.07	4 / 504
uterus	42%	74.69	72 / 170	4%	0.13	19 / 459
intestine	40%	30.11	382 / 966	0%	0.00	1 / 527
adrenal gland	9%	8.54	23 / 258	26%	1.71	59 / 230
heart	34%	39.71	297 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	30%	0.56	24 / 80
blood vessel	30%	26.16	399 / 1335	0%	0	0 / 0
adipose	20%	16.59	246 / 1204	0%	0	0 / 0
esophagus	19%	13.42	273 / 1445	1%	0.01	2 / 183
spleen	17%	11.68	41 / 241	0%	0	0 / 0
breast	15%	10.93	71 / 459	0%	0.01	2 / 1118
lung	5%	3.45	30 / 578	3%	0.20	31 / 1155
kidney	3%	2.74	3 / 89	1%	0.15	13 / 901
pancreas	0%	0	0 / 328	3%	0.28	5 / 178
liver	0%	0	0 / 226	1%	0.06	6 / 406
muscle	0%	0.12	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0032793	Biological process	positive regulation of CREB transcription factor activity
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0021766	Biological process	hippocampus development
GO_0019933	Biological process	cAMP-mediated signaling
GO_0043087	Biological process	regulation of GTPase activity
GO_0061178	Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0048666	Biological process	neuron development
GO_0006468	Biological process	protein phosphorylation
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0007411	Biological process	axon guidance
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0030424	Cellular component	axon
GO_0005791	Cellular component	rough endoplasmic reticulum
GO_0005004	Molecular function	GPI-linked ephrin receptor activity
GO_0005003	Molecular function	ephrin receptor activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	EPHA5
Protein name	receptor protein-tyrosine kinase (EC 2.7.10.1) Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Synonyms	hCG_1810817 BSK EHK1 HEK7 TYRO4
Description	FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). .
Accessions	B7ZKJ3 ENST00000273854.7 [P54756-1] ENST00000511294.1 B7ZKW7 ENST00000354839.8 [P54756-2] ENST00000613740.5 ENST00000432638.6 A0A384MU00 P54756 F8VP57 ENST00000622150.4 F8W9W0

EPHA5 report