ACKR4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACKR4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	92%	277.71	424 / 459	65%	2.07	731 / 1118
pancreas	63%	61.73	205 / 328	84%	3.42	149 / 178
lung	99%	227.75	571 / 578	43%	1.73	501 / 1155
stomach	84%	168.45	303 / 359	55%	4.24	157 / 286
esophagus	55%	81.71	794 / 1445	71%	3.47	130 / 183
skin	98%	547.97	1770 / 1809	25%	0.87	118 / 472
uterus	78%	209.21	133 / 170	38%	2.39	173 / 459
intestine	76%	108.40	730 / 966	37%	1.77	194 / 527
kidney	36%	32.64	32 / 89	74%	2.93	664 / 901
bladder	71%	106.00	15 / 21	34%	1.16	172 / 504
blood vessel	90%	336.42	1205 / 1335	0%	0	0 / 0
adipose	88%	401.69	1054 / 1204	0%	0	0 / 0
adrenal gland	75%	64.55	194 / 258	7%	0.14	15 / 230
heart	80%	141.78	689 / 861	0%	0	0 / 0
ovary	44%	36.65	79 / 180	30%	1.10	129 / 430
thymus	60%	69.95	395 / 653	11%	0.19	68 / 605
spleen	63%	47.98	153 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	47%	2.52	21 / 45
lymph node	0%	0	0 / 0	24%	0.61	7 / 29
brain	1%	0.59	26 / 2642	17%	0.34	118 / 705
prostate	16%	11.12	40 / 245	1%	0.04	7 / 502
liver	8%	5.17	19 / 226	3%	0.12	14 / 406
peripheral blood	6%	4.00	57 / 929	0%	0	0 / 0
muscle	5%	4.55	43 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.03	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006955	Biological process	immune response
GO_0016192	Biological process	vesicle-mediated transport
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0006935	Biological process	chemotaxis
GO_0019722	Biological process	calcium-mediated signaling
GO_0060326	Biological process	cell chemotaxis
GO_0009897	Cellular component	external side of plasma membrane
GO_0005769	Cellular component	early endosome
GO_0005886	Cellular component	plasma membrane
GO_0055037	Cellular component	recycling endosome
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0004950	Molecular function	chemokine receptor activity
GO_0005515	Molecular function	protein binding
GO_0005044	Molecular function	scavenger receptor activity

Gene name	ACKR4
Protein name	Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR) Atypical chemokine receptor 4
Synonyms	CCRL1 CCBP2 VSHK1 CCR11
Description	FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. .
Accessions	H0Y9Z2 ENST00000249887.3 Q9NPB9 ENST00000509820.1

ACKR4 report