Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 41 studies | 40% ± 17% | |
| oligodendrocyte precursor cell | 14 studies | 62% ± 23% | |
| connective tissue cell | 13 studies | 41% ± 15% | |
| myofibroblast cell | 9 studies | 37% ± 13% | |
| adventitial cell | 5 studies | 34% ± 11% | |
| smooth muscle cell | 3 studies | 26% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 10582.76 | 455 / 459 | 88% | 17.98 | 986 / 1118 |
| lung | 99% | 13565.67 | 574 / 578 | 87% | 15.78 | 1004 / 1155 |
| stomach | 97% | 8207.00 | 350 / 359 | 86% | 16.81 | 247 / 286 |
| esophagus | 97% | 8225.65 | 1398 / 1445 | 85% | 15.24 | 156 / 183 |
| intestine | 100% | 11703.01 | 966 / 966 | 80% | 12.36 | 422 / 527 |
| bladder | 100% | 17558.52 | 21 / 21 | 68% | 8.68 | 341 / 504 |
| brain | 66% | 2624.38 | 1741 / 2642 | 98% | 115.16 | 689 / 705 |
| ovary | 100% | 42348.41 | 180 / 180 | 55% | 6.95 | 237 / 430 |
| pancreas | 60% | 2220.77 | 196 / 328 | 94% | 27.57 | 167 / 178 |
| uterus | 100% | 15224.57 | 170 / 170 | 50% | 8.61 | 228 / 459 |
| prostate | 90% | 4611.20 | 221 / 245 | 56% | 5.48 | 283 / 502 |
| skin | 91% | 13458.19 | 1642 / 1809 | 42% | 4.80 | 197 / 472 |
| thymus | 94% | 5907.27 | 617 / 653 | 23% | 1.79 | 140 / 605 |
| adrenal gland | 93% | 6053.48 | 240 / 258 | 22% | 2.21 | 50 / 230 |
| adipose | 100% | 14038.86 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 10164.07 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 98% | 15742.57 | 237 / 241 | 0% | 0 | 0 / 0 |
| kidney | 75% | 4935.19 | 67 / 89 | 22% | 3.60 | 201 / 901 |
| heart | 80% | 5082.92 | 692 / 861 | 0% | 0 | 0 / 0 |
| liver | 35% | 1118.89 | 79 / 226 | 26% | 3.88 | 106 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 5.66 | 24 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 3.49 | 15 / 29 |
| muscle | 38% | 1190.57 | 302 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.06 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0010544 | Biological process | negative regulation of platelet activation |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0030324 | Biological process | lung development |
| GO_0034614 | Biological process | cellular response to reactive oxygen species |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0070527 | Biological process | platelet aggregation |
| GO_0001553 | Biological process | luteinization |
| GO_0050921 | Biological process | positive regulation of chemotaxis |
| GO_0048704 | Biological process | embryonic skeletal system morphogenesis |
| GO_0007275 | Biological process | multicellular organism development |
| GO_0030198 | Biological process | extracellular matrix organization |
| GO_0035790 | Biological process | platelet-derived growth factor receptor-alpha signaling pathway |
| GO_0038091 | Biological process | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO_2000739 | Biological process | regulation of mesenchymal stem cell differentiation |
| GO_0055003 | Biological process | cardiac myofibril assembly |
| GO_0061298 | Biological process | retina vasculature development in camera-type eye |
| GO_0042060 | Biological process | wound healing |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0033674 | Biological process | positive regulation of kinase activity |
| GO_0072277 | Biological process | metanephric glomerular capillary formation |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0001775 | Biological process | cell activation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0030539 | Biological process | male genitalia development |
| GO_0048557 | Biological process | embryonic digestive tract morphogenesis |
| GO_0030325 | Biological process | adrenal gland development |
| GO_0071230 | Biological process | cellular response to amino acid stimulus |
| GO_0008210 | Biological process | estrogen metabolic process |
| GO_0048701 | Biological process | embryonic cranial skeleton morphogenesis |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0033327 | Biological process | Leydig cell differentiation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0060325 | Biological process | face morphogenesis |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0050872 | Biological process | white fat cell differentiation |
| GO_0005902 | Cellular component | microvillus |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005929 | Cellular component | cilium |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030054 | Cellular component | cell junction |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005021 | Molecular function | vascular endothelial growth factor receptor activity |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0038085 | Molecular function | vascular endothelial growth factor binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0004714 | Molecular function | transmembrane receptor protein tyrosine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0048407 | Molecular function | platelet-derived growth factor binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005018 | Molecular function | platelet-derived growth factor alpha-receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PDGFRA |
| Protein name | Platelet-derived growth factor receptor-like protein Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) Platelet derived growth factor receptor alpha |
| Synonyms | PDGFR2 RHEPDGFRA |
| Description | FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. . |
| Accessions | D6RDX0 D6RG11 ENST00000508170.5 [P16234-2] ENST00000509490.5 [P16234-3] P16234 A0A387LBM6 D6RIG5 D6RJH0 ENST00000512143.1 ENST00000503856.5 ENST00000512522.1 ENST00000257290.10 [P16234-1] ENST00000504461.5 |
