CLEC4A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLEC4A at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0061760Biological processantifungal innate immune response
GO_0002470Biological processplasmacytoid dendritic cell antigen processing and presentation
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0007155Biological processcell adhesion
GO_0007166Biological processcell surface receptor signaling pathway
GO_0036037Biological processCD8-positive, alpha-beta T cell activation
GO_0001818Biological processnegative regulation of cytokine production
GO_0042590Biological processantigen processing and presentation of exogenous peptide antigen via MHC class I
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005537Molecular functionD-mannose binding
GO_0005509Molecular functioncalcium ion binding
GO_0030246Molecular functioncarbohydrate binding

IV. Literature review

[source]
Gene nameCLEC4A
Protein nameC-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)
C-type lectin domain family 4 member A
SynonymsLLIR
CLECSF6
HDCGC13P
DCIR
DescriptionFUNCTION: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner . Involved in regulating immune reactivity . Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 . In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production . May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation . .; FUNCTION: (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. .

AccessionsA0A286YF15
ENST00000345999.9 [Q9UMR7-4]
ENST00000641376.1
Q9UMR7
ENST00000360500.5 [Q9UMR7-3]
ENST00000352620.9 [Q9UMR7-2]
ENST00000229332.12 [Q9UMR7-1]