B4GALT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0007339Biological processbinding of sperm to zona pellucida
GO_0060054Biological processpositive regulation of epithelial cell proliferation involved in wound healing
GO_0009312Biological processoligosaccharide biosynthetic process
GO_0060055Biological processangiogenesis involved in wound healing
GO_0030198Biological processextracellular matrix organization
GO_0060046Biological processregulation of acrosome reaction
GO_0007155Biological processcell adhesion
GO_0061755Biological processpositive regulation of circulating fibrinogen levels
GO_0002526Biological processacute inflammatory response
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0006012Biological processgalactose metabolic process
GO_0045136Biological processdevelopment of secondary sexual characteristics
GO_1905517Biological processmacrophage migration
GO_0005989Biological processlactose biosynthetic process
GO_0006487Biological processprotein N-linked glycosylation
GO_0006629Biological processlipid metabolic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0002064Biological processepithelial cell development
GO_0007341Biological processpenetration of zona pellucida
GO_0031526Cellular componentbrush border membrane
GO_0005615Cellular componentextracellular space
GO_0030667Cellular componentsecretory granule membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0000138Cellular componentGolgi trans cisterna
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0030175Cellular componentfilopodium
GO_0000139Cellular componentGolgi membrane
GO_0030057Cellular componentdesmosome
GO_0032580Cellular componentGolgi cisterna membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0003831Molecular functionbeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO_0003945Molecular functionN-acetyllactosamine synthase activity
GO_0035250Molecular functionUDP-galactosyltransferase activity
GO_0008378Molecular functiongalactosyltransferase activity
GO_0004461Molecular functionlactose synthase activity
GO_0030145Molecular functionmanganese ion binding
GO_0008092Molecular functioncytoskeletal protein binding

IV. Literature review

[source]
Gene nameB4GALT1
Protein nameBeta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
Beta-1,4-galactosyltransferase 1
B4GALT1 protein (Beta-1,4-galactosyltransferase 1)
Beta-1,4-galactosyltransferase (Beta-1,4-GalTase) (EC 2.4.1.-)
SynonymsGGTB2
DescriptionFUNCTION: [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. .

FUNCTION: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .

AccessionsENST00000535206.5
Q86XA6
P15291
ENST00000379731.5 [P15291-1]
W6MEN3
W6MEN4