HYAL2 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	48% ± 22%	Explore
endothelial cell of lymphatic vessel	22 studies	52% ± 21%	Explore
capillary endothelial cell	15 studies	55% ± 23%	Explore
endothelial cell of artery	13 studies	56% ± 17%	Explore
vein endothelial cell	12 studies	57% ± 19%	Explore
endothelial cell of vascular tree	10 studies	39% ± 22%	Explore
pericyte	7 studies	34% ± 21%	Explore
glomerular endothelial cell	4 studies	67% ± 8%	Explore
type I pneumocyte	4 studies	23% ± 7%	Explore
epithelial cell	3 studies	36% ± 10%	Explore
basal cell	3 studies	39% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	27% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4540.78	258 / 258	100%	45.49	230 / 230
uterus	100%	4709.88	170 / 170	100%	37.39	459 / 459
kidney	100%	4970.03	89 / 89	100%	49.11	897 / 901
thymus	100%	6756.78	653 / 653	100%	62.09	602 / 605
lung	100%	14739.29	578 / 578	99%	36.47	1148 / 1155
stomach	100%	2294.68	359 / 359	99%	32.48	284 / 286
breast	100%	6957.79	459 / 459	99%	36.30	1109 / 1118
esophagus	100%	2906.41	1441 / 1445	99%	20.94	182 / 183
skin	100%	2278.87	1800 / 1809	100%	39.83	470 / 472
bladder	100%	3579.48	21 / 21	99%	39.85	499 / 504
prostate	100%	3137.59	244 / 245	99%	32.71	498 / 502
intestine	99%	2451.07	953 / 966	99%	38.23	521 / 527
ovary	96%	2081.19	173 / 180	100%	38.25	430 / 430
liver	80%	1323.62	181 / 226	100%	26.92	406 / 406
pancreas	75%	994.10	247 / 328	100%	46.07	178 / 178
brain	66%	996.87	1754 / 2642	100%	33.82	704 / 705
adipose	100%	6801.19	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.47	29 / 29
spleen	100%	24473.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.22	45 / 45
ureter	0%	0	0 / 0	100%	43.47	1 / 1
heart	98%	3432.06	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	13.59	73 / 80
blood vessel	85%	2173.08	1134 / 1335	0%	0	0 / 0
muscle	77%	1155.92	619 / 803	0%	0	0 / 0
peripheral blood	27%	343.86	255 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_2001238	Biological process	positive regulation of extrinsic apoptotic signaling pathway
GO_0042117	Biological process	monocyte activation
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0009615	Biological process	response to virus
GO_0005975	Biological process	carbohydrate metabolic process
GO_0051607	Biological process	defense response to virus
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_0001822	Biological process	kidney development
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0071347	Biological process	cellular response to interleukin-1
GO_0030214	Biological process	hyaluronan catabolic process
GO_0010764	Biological process	negative regulation of fibroblast migration
GO_0006027	Biological process	glycosaminoglycan catabolic process
GO_0071493	Biological process	cellular response to UV-B
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0046718	Biological process	symbiont entry into host cell
GO_0070295	Biological process	renal water absorption
GO_0019064	Biological process	fusion of virus membrane with host plasma membrane
GO_0046677	Biological process	response to antibiotic
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0000302	Biological process	response to reactive oxygen species
GO_0061099	Biological process	negative regulation of protein tyrosine kinase activity
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0051216	Biological process	cartilage development
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0035810	Biological process	positive regulation of urine volume
GO_0048705	Biological process	skeletal system morphogenesis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0030308	Biological process	negative regulation of cell growth
GO_0005902	Cellular component	microvillus
GO_0016324	Cellular component	apical plasma membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0030139	Cellular component	endocytic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005764	Cellular component	lysosome
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0090575	Cellular component	RNA polymerase II transcription regulator complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0019899	Molecular function	enzyme binding
GO_0030294	Molecular function	receptor signaling protein tyrosine kinase inhibitor activity
GO_0004415	Molecular function	hyalurononglucosaminidase activity
GO_0033906	Molecular function	hyaluronoglucuronidase activity
GO_0001618	Molecular function	virus receptor activity
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding
GO_0005540	Molecular function	hyaluronic acid binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

IV. Literature review

[source]

Gene name	HYAL2
Protein name	Hyaluronidase (EC 3.2.1.35) Hyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2) Hyaluronoglucosaminidase 2 Hyaluronidase 2
Synonyms	LUCA2
Description	FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. . FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. . FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. . FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. . FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. . FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. .
Accessions	ENST00000442581.1 C9JSI7 Q12891 ENST00000424190.1 ENST00000395139.7 C9K016 ENST00000357750.9 C9JSD1 ENST00000428028.1 C9JBF5 ENST00000415028.1 ENST00000426286.1 Q5ZEZ9 ENST00000447092.5 Q5ZF00 C9J700 ENST00000458018.1

HYAL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review