CD3E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042102Biological processpositive regulation of T cell proliferation
GO_0097190Biological processapoptotic signaling pathway
GO_0007224Biological processsmoothened signaling pathway
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0019722Biological processcalcium-mediated signaling
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0010629Biological processnegative regulation of gene expression
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0046629Biological processgamma-delta T cell activation
GO_0031295Biological processT cell costimulation
GO_0010628Biological processpositive regulation of gene expression
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0033634Biological processpositive regulation of cell-cell adhesion mediated by integrin
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0046631Biological processalpha-beta T cell activation
GO_0050852Biological processT cell receptor signaling pathway
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0065003Biological processprotein-containing complex assembly
GO_0002250Biological processadaptive immune response
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0002870Biological processT cell anergy
GO_2000563Biological processpositive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0007172Biological processsignal complex assembly
GO_0021549Biological processcerebellum development
GO_0032729Biological processpositive regulation of type II interferon production
GO_0045059Biological processpositive thymic T cell selection
GO_0002669Biological processpositive regulation of T cell anergy
GO_0045060Biological processnegative thymic T cell selection
GO_0016358Biological processdendrite development
GO_0042110Biological processT cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0001772Cellular componentimmunological synapse
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0005794Cellular componentGolgi apparatus
GO_0042105Cellular componentalpha-beta T cell receptor complex
GO_0005911Cellular componentcell-cell junction
GO_0005783Cellular componentendoplasmic reticulum
GO_0044297Cellular componentcell body
GO_0042101Cellular componentT cell receptor complex
GO_0042106Cellular componentgamma-delta T cell receptor complex
GO_0042608Molecular functionT cell receptor binding
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0017124Molecular functionSH3 domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD3E
Protein nameT-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
CD3E protein
T-cell surface glycoprotein CD3 epsilon chain
SynonymsT3E
DescriptionFUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region . .

AccessionsP07766
E9PSH8
ENST00000361763.9
A0N2Z5
ENST00000528600.1