CLEC12B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CLEC12B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLEC12B at tissue level.

III. Associated gene sets

GO_0002769Biological processnatural killer cell inhibitory signaling pathway
GO_0045953Biological processnegative regulation of natural killer cell mediated cytotoxicity
GO_1904893Biological processnegative regulation of receptor signaling pathway via STAT
GO_0097325Biological processmelanocyte proliferation
GO_2000272Biological processnegative regulation of signaling receptor activity
GO_0032991Cellular componentprotein-containing complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0030547Molecular functionsignaling receptor inhibitor activity
GO_0030246Molecular functioncarbohydrate binding
GO_0019903Molecular functionprotein phosphatase binding

IV. Literature review

[source]
Gene nameCLEC12B
Protein nameC-type lectin domain family 12 member B (Macrophage antigen H)
C-type lectin domain family 12 member B
C-type lectin domain family 12, member B
SynonymsUNQ5782/PRO16089
DescriptionFUNCTION: Inhibitory receptor postulated to negatively regulate immune and non-immune functions . Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals . Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart . May limit activation of myeloid cell subsets in response to infection or tissue inflammation . May protect target cells against natural killer cell-mediated lysis . May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 . .

AccessionsENST00000338896.11 [Q2HXU8-1]
ENST00000396502.5 [Q2HXU8-2]
Q2HXU8
B2RNC6
ENST00000539155.1
ENST00000544853.5 [Q2HXU8-2]
F5H4H7