CRLF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CRLF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CRLF2 at tissue level.

III. Associated gene sets

GO_0033005Biological processpositive regulation of mast cell activation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0019221Biological processcytokine-mediated signaling pathway
GO_1904894Biological processpositive regulation of receptor signaling pathway via STAT
GO_0032754Biological processpositive regulation of interleukin-5 production
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0019955Molecular functioncytokine binding
GO_0004896Molecular functioncytokine receptor activity

IV. Literature review

[source]
Gene nameCRLF2
Protein nameCytokine receptor like factor 2
Cytokine receptor-like factor 2
Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)
SynonymsTSLPR
CRL2
fusion
ILXR
P2RY8
DescriptionFUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. .

AccessionsENST00000711256.1 [Q9HC73-3]
ENST00000467626.6
ENST00000400841.8 [Q9HC73-1]
ENST00000711255.1
ENST00000381567.8 [Q9HC73-3]
Q9HC73
D0E2W4
ENST00000711254.1 [Q9HC73-1]
A0A0C4DH06