Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| regulatory T cell | 24 studies | 44% ± 13% | |
| T follicular helper cell | 4 studies | 34% ± 11% | |
| CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 1% | |
| T cell | 3 studies | 25% ± 8% |
Insufficient scRNA-seq data for expression of CTLA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 268.47 | 577 / 578 | 92% | 6.18 | 1064 / 1155 |
| intestine | 78% | 184.84 | 750 / 966 | 84% | 4.38 | 442 / 527 |
| stomach | 72% | 43.12 | 257 / 359 | 85% | 4.39 | 244 / 286 |
| breast | 86% | 69.92 | 395 / 459 | 71% | 3.83 | 790 / 1118 |
| prostate | 82% | 76.18 | 201 / 245 | 57% | 1.83 | 286 / 502 |
| bladder | 62% | 57.52 | 13 / 21 | 75% | 4.37 | 378 / 504 |
| esophagus | 49% | 41.36 | 714 / 1445 | 86% | 5.06 | 157 / 183 |
| thymus | 78% | 115.15 | 508 / 653 | 57% | 2.66 | 345 / 605 |
| skin | 51% | 27.51 | 919 / 1809 | 82% | 11.22 | 385 / 472 |
| uterus | 48% | 19.08 | 81 / 170 | 78% | 5.12 | 356 / 459 |
| kidney | 64% | 65.87 | 57 / 89 | 49% | 1.83 | 438 / 901 |
| spleen | 100% | 365.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 35.25 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 12.25 | 43 / 45 |
| pancreas | 9% | 2.69 | 31 / 328 | 81% | 4.46 | 144 / 178 |
| adipose | 88% | 56.39 | 1060 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 134.81 | 756 / 929 | 0% | 0 | 0 / 0 |
| liver | 31% | 10.97 | 70 / 226 | 42% | 1.60 | 171 / 406 |
| ovary | 30% | 10.37 | 54 / 180 | 43% | 1.10 | 184 / 430 |
| blood vessel | 61% | 35.74 | 808 / 1335 | 0% | 0 | 0 / 0 |
| heart | 41% | 14.84 | 356 / 861 | 0% | 0 | 0 / 0 |
| brain | 22% | 6.96 | 592 / 2642 | 16% | 0.62 | 110 / 705 |
| adrenal gland | 21% | 6.84 | 53 / 258 | 13% | 0.27 | 31 / 230 |
| eye | 0% | 0 | 0 / 0 | 10% | 0.26 | 8 / 80 |
| muscle | 8% | 3.26 | 65 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006955 | Biological process | immune response |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0006974 | Biological process | DNA damage response |
| GO_0050853 | Biological process | B cell receptor signaling pathway |
| GO_0045590 | Biological process | negative regulation of regulatory T cell differentiation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0030889 | Biological process | negative regulation of B cell proliferation |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0098636 | Cellular component | protein complex involved in cell adhesion |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CTLA4 |
| Protein name | Cytotoxic T-lymphocyte-associated protein 4 Alternative protein CTLA4 Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) Cytotoxic T-lymphocyte antigen 4 Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152) |
| Synonyms | CD152 |
| Description | FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. . FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. . FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. . FUNCTION: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. . |
| Accessions | E9L3G1 Q0Q5F0 ENST00000295854.10 [P16410-5] ENST00000696049.1 Q0Q5F1 ENST00000648405.2 [P16410-1] ENST00000487393.1 [P16410-3] L8E9B1 A0A8Q3SIR7 ENST00000696479.1 E9L3G0 P16410 A0A8Q3WKZ2 E9L3G3 Q6GR94 |
