I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 43% ± 1% | |
| macrophage | 5 studies | 27% ± 8% | |
| glutamatergic neuron | 4 studies | 33% ± 14% | |
| GABAergic neuron | 3 studies | 26% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 43% ± 1% | |
| macrophage | 5 studies | 27% ± 8% | |
| glutamatergic neuron | 4 studies | 33% ± 14% | |
| GABAergic neuron | 3 studies | 26% ± 12% |
Insufficient scRNA-seq data for expression of GFRA2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2985.12 | 651 / 653 | 94% | 19.44 | 569 / 605 |
| brain | 81% | 872.25 | 2136 / 2642 | 90% | 8.84 | 635 / 705 |
| adrenal gland | 41% | 211.84 | 107 / 258 | 80% | 23.17 | 183 / 230 |
| intestine | 95% | 446.78 | 920 / 966 | 10% | 0.24 | 52 / 527 |
| spleen | 98% | 1872.86 | 237 / 241 | 0% | 0 | 0 / 0 |
| bladder | 86% | 244.24 | 18 / 21 | 11% | 0.40 | 55 / 504 |
| prostate | 68% | 214.02 | 167 / 245 | 24% | 0.39 | 122 / 502 |
| adipose | 85% | 367.39 | 1025 / 1204 | 0% | 0 | 0 / 0 |
| lung | 66% | 176.09 | 382 / 578 | 18% | 0.43 | 213 / 1155 |
| breast | 65% | 184.87 | 298 / 459 | 17% | 0.54 | 186 / 1118 |
| uterus | 59% | 257.89 | 100 / 170 | 20% | 1.10 | 92 / 459 |
| skin | 44% | 112.07 | 796 / 1809 | 34% | 4.36 | 159 / 472 |
| kidney | 36% | 88.04 | 32 / 89 | 39% | 1.15 | 352 / 901 |
| esophagus | 66% | 365.76 | 950 / 1445 | 6% | 0.10 | 11 / 183 |
| ovary | 31% | 60.83 | 55 / 180 | 31% | 2.01 | 135 / 430 |
| stomach | 51% | 230.89 | 183 / 359 | 10% | 0.19 | 29 / 286 |
| blood vessel | 58% | 145.74 | 772 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 1.60 | 14 / 29 |
| heart | 46% | 121.96 | 397 / 861 | 0% | 0 | 0 / 0 |
| liver | 12% | 23.43 | 26 / 226 | 33% | 0.83 | 132 / 406 |
| pancreas | 2% | 2.84 | 5 / 328 | 28% | 0.61 | 50 / 178 |
| eye | 0% | 0 | 0 / 0 | 23% | 0.44 | 18 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 0.45 | 10 / 45 |
| peripheral blood | 20% | 53.17 | 184 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.92 | 11 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0007399 | Biological process | nervous system development |
| GO_0035860 | Biological process | glial cell-derived neurotrophic factor receptor signaling pathway |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0019898 | Cellular component | extrinsic component of membrane |
| GO_1904399 | Molecular function | heparan sulfate binding |
| GO_0016167 | Molecular function | glial cell-derived neurotrophic factor receptor activity |
| Gene name | GFRA2 |
| Protein name | GDNF family receptor alpha 2 GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2) GDNF family receptor alpha-2 |
| Synonyms | GDNFRB RETL2 TRNR2 |
| Description | FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; FUNCTION: [Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. . FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. . |
| Accessions | ENST00000518077.5 [O00451-2] O00451 E5RJ44 ENST00000517892.5 [O00451-3] J3KNF0 ENST00000306793.4 E5RGR6 ENST00000524240.6 [O00451-1] ENST00000522071.2 ENST00000517328.5 [O00451-1] ENST00000519195.1 |
