ITGA3 | OmnibusX

Name	Number of supported studies	Average coverage
type I pneumocyte	12 studies	47% ± 11%	Explore
basal cell	11 studies	27% ± 18%	Explore
ciliated cell	10 studies	25% ± 5%	Explore
epithelial cell	7 studies	24% ± 9%	Explore
capillary endothelial cell	6 studies	22% ± 6%	Explore
type II pneumocyte	6 studies	25% ± 6%	Explore
mesothelial cell	5 studies	28% ± 11%	Explore
endothelial cell	5 studies	26% ± 6%	Explore
club cell	5 studies	25% ± 8%	Explore
podocyte	4 studies	36% ± 16%	Explore
GABAergic neuron	3 studies	38% ± 12%	Explore
glutamatergic neuron	3 studies	46% ± 12%	Explore
smooth muscle cell	3 studies	22% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	23% ± 6%	Explore
brain	3 studies	30% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6420.46	1438 / 1445	97%	146.47	177 / 183
thymus	100%	15689.45	653 / 653	91%	257.29	550 / 605
lung	100%	17338.16	578 / 578	91%	136.02	1049 / 1155
kidney	100%	19287.91	89 / 89	90%	166.10	808 / 901
ovary	97%	3734.56	175 / 180	90%	84.22	385 / 430
intestine	99%	5900.76	960 / 966	85%	61.94	448 / 527
bladder	100%	7396.86	21 / 21	84%	136.81	424 / 504
stomach	98%	5531.38	353 / 359	83%	60.44	236 / 286
uterus	100%	5848.77	170 / 170	77%	101.80	352 / 459
skin	98%	8013.35	1775 / 1809	78%	141.11	366 / 472
pancreas	72%	2236.72	236 / 328	93%	166.25	165 / 178
adrenal gland	100%	7849.07	258 / 258	62%	37.87	143 / 230
breast	97%	5292.63	444 / 459	58%	32.16	652 / 1118
prostate	100%	7839.82	245 / 245	40%	14.61	200 / 502
blood vessel	100%	19554.80	1334 / 1335	0%	0	0 / 0
spleen	97%	3923.22	234 / 241	0%	0	0 / 0
adipose	96%	4605.50	1153 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	112.48	40 / 45
eye	0%	0	0 / 0	85%	64.93	68 / 80
brain	50%	1577.90	1319 / 2642	21%	14.53	146 / 705
heart	70%	2170.91	603 / 861	0%	0	0 / 0
muscle	31%	803.84	251 / 803	0%	0	0 / 0
liver	2%	63.27	4 / 226	11%	12.20	46 / 406
peripheral blood	0%	6.84	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0035024	Biological process	negative regulation of Rho protein signal transduction
GO_0097205	Biological process	renal filtration
GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0030324	Biological process	lung development
GO_0035640	Biological process	exploration behavior
GO_0034698	Biological process	response to gonadotropin
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007507	Biological process	heart development
GO_0007160	Biological process	cell-matrix adhesion
GO_0010811	Biological process	positive regulation of cell-substrate adhesion
GO_0030510	Biological process	regulation of BMP signaling pathway
GO_0010628	Biological process	positive regulation of gene expression
GO_0099560	Biological process	synaptic membrane adhesion
GO_0001764	Biological process	neuron migration
GO_0048333	Biological process	mesodermal cell differentiation
GO_0031345	Biological process	negative regulation of cell projection organization
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0050900	Biological process	leukocyte migration
GO_0072006	Biological process	nephron development
GO_0097062	Biological process	dendritic spine maintenance
GO_0007613	Biological process	memory
GO_0007266	Biological process	Rho protein signal transduction
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0030111	Biological process	regulation of Wnt signaling pathway
GO_0043588	Biological process	skin development
GO_0098609	Biological process	cell-cell adhesion
GO_0010634	Biological process	positive regulation of epithelial cell migration
GO_0060135	Biological process	maternal process involved in female pregnancy
GO_0016323	Cellular component	basolateral plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0097060	Cellular component	synaptic membrane
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0008305	Cellular component	integrin complex
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0031527	Cellular component	filopodium membrane
GO_0009986	Cellular component	cell surface
GO_0071944	Cellular component	cell periphery
GO_0045211	Cellular component	postsynaptic membrane
GO_1990812	Cellular component	growth cone filopodium
GO_0060076	Cellular component	excitatory synapse
GO_0034667	Cellular component	integrin alpha3-beta1 complex
GO_0019904	Molecular function	protein domain specific binding
GO_0001968	Molecular function	fibronectin binding
GO_0005178	Molecular function	integrin binding
GO_0002020	Molecular function	protease binding
GO_0046872	Molecular function	metal ion binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0043236	Molecular function	laminin binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ITGA3
Protein name	Integrin subunit alpha 3 Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
Synonyms	MSK18
Description	FUNCTION: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. .; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. .
Accessions	D6R9X8 K7EMU3 ENST00000504417.1 ENST00000007722.11 [P26006-1] ENST00000320031.13 [P26006-2] H0YA49 P26006 ENST00000506401.6 ENST00000506827.1 ENST00000510809.1 ENST00000512553.5 K7EQJ2 H0YA32

ITGA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review