MFGE8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0043277Biological processapoptotic cell clearance
GO_0007338Biological processsingle fertilization
GO_0007155Biological processcell adhesion
GO_0002080Cellular componentacrosomal membrane
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0070062Cellular componentextracellular exosome
GO_0009897Cellular componentexternal side of plasma membrane
GO_1903561Cellular componentextracellular vesicle
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0016020Cellular componentmembrane
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0001786Molecular functionphosphatidylserine binding
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameMFGE8
Protein nameLactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
Milk fat globule EGF and factor V/VIII domain containing
Synonyms
DescriptionFUNCTION: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. .; FUNCTION: [Medin]: Main constituent of aortic medial amyloid. .

AccessionsQ08431
A0A8Q3SIZ9
H0YKS8
ENST00000542878.5 [Q08431-4]
A0A8Q3SIX6
ENST00000558018.5
A0A8Q3SI86
ENST00000695566.1 [Q08431-2]
A0A8Q3SIU8
ENST00000695774.1
ENST00000695568.1
ENST00000268150.13 [Q08431-1]
ENST00000695569.1
A0A8Q3WKS4
ENST00000558029.6
ENST00000268151.11 [Q08431-3]
H0YKB5
ENST00000566497.5 [Q08431-1]
ENST00000695570.1
ENST00000695567.1