SEMA7A | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	7 studies	28% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SEMA7A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	96%	2192.53	1731 / 1809	96%	67.05	453 / 472
brain	87%	2754.82	2295 / 2642	100%	33.99	703 / 705
lung	84%	1127.98	484 / 578	92%	16.95	1066 / 1155
ovary	86%	1120.17	154 / 180	72%	7.35	310 / 430
bladder	43%	298.81	9 / 21	90%	29.57	454 / 504
esophagus	34%	292.72	493 / 1445	82%	10.56	150 / 183
uterus	28%	173.92	47 / 170	88%	19.95	402 / 459
intestine	35%	487.08	342 / 966	77%	13.78	404 / 527
breast	21%	129.39	98 / 459	83%	10.20	927 / 1118
lymph node	0%	0	0 / 0	100%	87.02	29 / 29
spleen	100%	9293.32	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	79.89	1 / 1
stomach	19%	215.03	68 / 359	78%	11.38	223 / 286
tonsil	0%	0	0 / 0	96%	15.29	43 / 45
pancreas	1%	9.34	3 / 328	93%	56.63	166 / 178
adrenal gland	32%	209.19	83 / 258	42%	16.10	96 / 230
eye	0%	0	0 / 0	73%	13.36	58 / 80
peripheral blood	67%	5944.08	619 / 929	0%	0	0 / 0
kidney	20%	183.34	18 / 89	43%	4.36	391 / 901
liver	2%	13.63	5 / 226	59%	8.46	241 / 406
thymus	10%	77.11	64 / 653	51%	7.56	311 / 605
prostate	23%	139.66	57 / 245	15%	0.93	74 / 502
adipose	18%	126.48	222 / 1204	0%	0	0 / 0
blood vessel	11%	115.90	147 / 1335	0%	0	0 / 0
heart	8%	59.38	65 / 861	0%	0	0 / 0
muscle	3%	15.47	25 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006954	Biological process	inflammatory response
GO_0045773	Biological process	positive regulation of axon extension
GO_0001755	Biological process	neural crest cell migration
GO_0001649	Biological process	osteoblast differentiation
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0050727	Biological process	regulation of inflammatory response
GO_0021988	Biological process	olfactory lobe development
GO_0050919	Biological process	negative chemotaxis
GO_0006955	Biological process	immune response
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0030335	Biological process	positive regulation of cell migration
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0048675	Biological process	axon extension
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007411	Biological process	axon guidance
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0030215	Molecular function	semaphorin receptor binding
GO_0005178	Molecular function	integrin binding
GO_0045499	Molecular function	chemorepellent activity
GO_0005515	Molecular function	protein binding

Gene name	SEMA7A
Protein name	Semaphorin 7A Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) Semaphorin 7A (John Milton Hagen blood group)
Synonyms	CD108 SEMAL
Description	FUNCTION: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. .
Accessions	ENST00000543145.6 [O75326-2] O75326 ENST00000672978.1 [O75326-2] A0A7S9FTL9 ENST00000671713.1 [O75326-1] ENST00000542748.6 ENST00000261918.9 [O75326-1] F5GYX3

SEMA7A report