Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 11 studies | 38% ± 12% | |
| type II pneumocyte | 11 studies | 41% ± 16% | |
| basal cell | 5 studies | 21% ± 3% | |
| club cell | 5 studies | 22% ± 4% | |
| kidney loop of Henle epithelial cell | 4 studies | 24% ± 8% | |
| epithelial cell | 4 studies | 34% ± 11% | |
| secretory cell | 4 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 4 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 94% | 626.25 | 308 / 328 | 93% | 117.79 | 166 / 178 |
| lung | 99% | 3861.68 | 570 / 578 | 87% | 64.11 | 1007 / 1155 |
| thymus | 99% | 1027.27 | 649 / 653 | 60% | 15.80 | 360 / 605 |
| bladder | 62% | 1765.90 | 13 / 21 | 87% | 60.67 | 437 / 504 |
| kidney | 100% | 6347.91 | 89 / 89 | 43% | 20.64 | 388 / 901 |
| breast | 60% | 1185.36 | 275 / 459 | 76% | 46.56 | 848 / 1118 |
| stomach | 70% | 857.36 | 252 / 359 | 63% | 16.59 | 179 / 286 |
| esophagus | 39% | 1152.31 | 558 / 1445 | 89% | 56.84 | 163 / 183 |
| intestine | 41% | 495.65 | 398 / 966 | 73% | 21.19 | 385 / 527 |
| prostate | 87% | 1071.15 | 214 / 245 | 18% | 2.64 | 90 / 502 |
| ureter | 0% | 0 | 0 / 0 | 100% | 63.39 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 45.87 | 40 / 45 |
| uterus | 5% | 33.55 | 9 / 170 | 78% | 64.35 | 358 / 459 |
| muscle | 82% | 2358.48 | 662 / 803 | 0% | 0 | 0 / 0 |
| skin | 68% | 394.34 | 1234 / 1809 | 1% | 0.41 | 7 / 472 |
| heart | 47% | 159.14 | 406 / 861 | 0% | 0 | 0 / 0 |
| ovary | 1% | 7.32 | 1 / 180 | 33% | 8.10 | 143 / 430 |
| liver | 1% | 2.55 | 2 / 226 | 3% | 1.70 | 14 / 406 |
| adipose | 1% | 3.56 | 11 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.36 | 6 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.54 | 2 / 929 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.07 | 1 / 2642 | 0% | 0 | 0 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0 | 0 / 230 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0055091 | Biological process | phospholipid homeostasis |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0006954 | Biological process | inflammatory response |
| GO_0060435 | Biological process | bronchiole development |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0009615 | Biological process | response to virus |
| GO_0007155 | Biological process | cell adhesion |
| GO_0042060 | Biological process | wound healing |
| GO_0006955 | Biological process | immune response |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0043129 | Biological process | surfactant homeostasis |
| GO_0060022 | Biological process | hard palate development |
| GO_0070166 | Biological process | enamel mineralization |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0060348 | Biological process | bone development |
| GO_0071479 | Biological process | cellular response to ionizing radiation |
| GO_0043588 | Biological process | skin development |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0016477 | Biological process | cell migration |
| GO_0061520 | Biological process | Langerhans cell differentiation |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0071604 | Biological process | transforming growth factor beta production |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0008305 | Cellular component | integrin complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0009986 | Cellular component | cell surface |
| GO_0030054 | Cellular component | cell junction |
| GO_0034685 | Cellular component | integrin alphav-beta6 complex |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0005178 | Molecular function | integrin binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ITGB6 |
| Protein name | Integrin subunit beta 6 Integrin beta Integrin beta-6 |
| Synonyms | |
| Description | FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin . It recognizes the sequence R-G-D in its ligands . Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion . ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation . .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 . . |
| Accessions | ENST00000428609.6 ENST00000409872.1 [P18564-1] A0A087WXP3 E9PEE8 ENST00000409583.5 P18564 ENST00000409967.6 [P18564-2] F8WBJ8 ENST00000283249.7 [P18564-1] ENST00000620391.4 |
