PLAUR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_2001268Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0051917Biological processregulation of fibrinolysis
GO_0007165Biological processsignal transduction
GO_0006935Biological processchemotaxis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0007596Biological processblood coagulation
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0010755Biological processregulation of plasminogen activation
GO_0043388Biological processpositive regulation of DNA binding
GO_0034112Biological processpositive regulation of homotypic cell-cell adhesion
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0038195Biological processurokinase plasminogen activator signaling pathway
GO_0030162Biological processregulation of proteolysis
GO_0030155Biological processregulation of cell adhesion
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0019898Cellular componentextrinsic component of membrane
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0098637Cellular componentprotein complex involved in cell-matrix adhesion
GO_0042995Cellular componentcell projection
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0030377Molecular functionurokinase plasminogen activator receptor activity
GO_0019899Molecular functionenzyme binding
GO_0038023Molecular functionsignaling receptor activity
GO_0019904Molecular functionprotein domain specific binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLAUR
Protein nameUrokinase plasminogen activator surface receptor
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)
Plasminogen activator, urokinase receptor
Urokinase plasminogen activator receptor
SynonymsMO3
UPAR
DescriptionFUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. .

AccessionsM0R1I2
ENST00000340093.8 [Q03405-1]
ENST00000599546.1
M0R383
ENST00000593714.5
Q6GY32
M0R0Y4
ENST00000221264.8 [Q03405-3]
M0QX27
ENST00000597107.1
ENST00000339082.7 [Q03405-2]
Q9UPI5
M0R2E9
ENST00000593939.5
ENST00000595038.5
ENST00000601723.5
Q03405
M0R0L1
M0QYS6
M0R0H5
ENST00000602141.5
ENST00000593447.5
ENST00000599892.5
M0QYR6