CLEC4D report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLEC4D at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0061760Biological processantifungal innate immune response
GO_0030887Biological processpositive regulation of myeloid dendritic cell activation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0002292Biological processT cell differentiation involved in immune response
GO_0038094Biological processFc-gamma receptor signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0009897Cellular componentexternal side of plasma membrane
GO_0070821Cellular componenttertiary granule membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0034987Molecular functionimmunoglobulin receptor binding
GO_0005537Molecular functionD-mannose binding
GO_0030246Molecular functioncarbohydrate binding
GO_0038187Molecular functionpattern recognition receptor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCLEC4D
Protein nameC-type lectin domain family 4 member D
C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)
SynonymsCLECSF8
MCL
DescriptionFUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi . The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) . Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes . The heterodimer formed with CLEC6A is active against fungal infection . Functions as an endocytic receptor . May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells . .

AccessionsQ8WXI8
ENST00000299665.3
ENST00000382064.6
A6NHA5