NRCAM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0030516Biological processregulation of axon extension
GO_0099175Biological processregulation of postsynapse organization
GO_0045162Biological processclustering of voltage-gated sodium channels
GO_0001764Biological processneuron migration
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0007413Biological processaxonal fasciculation
GO_0007409Biological processaxonogenesis
GO_0007417Biological processcentral nervous system development
GO_0007420Biological processbrain development
GO_0010975Biological processregulation of neuron projection development
GO_0008104Biological processprotein localization
GO_0007416Biological processsynapse assembly
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0098609Biological processcell-cell adhesion
GO_0007411Biological processaxon guidance
GO_0019227Biological processneuronal action potential propagation
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0043194Cellular componentaxon initial segment
GO_0043005Cellular componentneuron projection
GO_0030424Cellular componentaxon
GO_0086080Molecular functionprotein binding involved in heterotypic cell-cell adhesion
GO_0098632Molecular functioncell-cell adhesion mediator activity
GO_0030506Molecular functionankyrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNRCAM
Protein nameNeuronal cell adhesion molecule short isoform
Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
Neuronal cell adhesion molecule
NRCAM protein
Uncharacterized protein NRCAM
SynonymsKIAA0343
DescriptionFUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. .

AccessionsQ14CA1
Q6QRP2
ENST00000351718.8 [Q92823-4]
ENST00000419936.5
Q92823
ENST00000445634.2
C9J8B6
ENST00000418239.1
A0A1B1PFW4
C9JH43
C9JYY6
C9JUR7
C9JF43
ENST00000379024.8 [Q92823-6]
ENST00000413765.6
Q4KMQ7
ENST00000442580.5
A0A1S5UZH4
ENST00000417701.5
Q75ML9
ENST00000456431.5
ENST00000379028.8 [Q92823-1]
H7C132