IDE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010815Biological processbradykinin catabolic process
GO_0050435Biological processamyloid-beta metabolic process
GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0032092Biological processpositive regulation of protein binding
GO_0010992Biological processubiquitin recycling
GO_0042447Biological processhormone catabolic process
GO_0097242Biological processamyloid-beta clearance
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0046718Biological processsymbiont entry into host cell
GO_0008286Biological processinsulin receptor signaling pathway
GO_0006508Biological processproteolysis
GO_0150094Biological processamyloid-beta clearance by cellular catabolic process
GO_1901142Biological processinsulin metabolic process
GO_0030163Biological processprotein catabolic process
GO_1901143Biological processinsulin catabolic process
GO_1903715Biological processregulation of aerobic respiration
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0043171Biological processpeptide catabolic process
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005777Cellular componentperoxisome
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0005737Cellular componentcytoplasm
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0004175Molecular functionendopeptidase activity
GO_0042277Molecular functionpeptide binding
GO_0001618Molecular functionvirus receptor activity
GO_0043559Molecular functioninsulin binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIDE
Protein nameInsulin degrading enzyme
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Insulin degrading enzyme (cDNA FLJ35968 fis, clone TESTI2013053, highly similar to INSULIN-DEGRADING ENZYME)
Synonyms
DescriptionFUNCTION: Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling . Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin . Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (Probable). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP . Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients . Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I. .; FUNCTION: (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). .

AccessionsENST00000677434.1
R4GN65
P14735
A0A7I2V2P6
ENST00000678824.1
A0A7I2V4A4
ENST00000679089.1
ENST00000650060.2
A0A7I2V4Q3
A0A7I2YQV5
ENST00000676540.1
A0A3B3ISG5
ENST00000678844.1
A0A7I2V2S1
A0A7I2V3E3
A0A7I2V373
A0A7I2V610
ENST00000677079.1
A0A7I2V612
ENST00000478361.6
ENST00000677096.1
ENST00000679222.1
ENST00000679232.1
A0A7I2V634
ENST00000496903.5
ENST00000679312.1
ENST00000371581.9 [P14735-2]
ENST00000265986.11 [P14735-1]
ENST00000678673.1
A0A7I2YQS6
ENST00000679174.1
ENST00000676816.1
ENST00000677569.1
ENST00000677978.1
ENST00000678715.1
A0A7I2V3K9
B3KSB8